International Immunology, Vol 9, 73-79, Copyright © 1997 by Oxford University Press
MC Leite-de-Moraes, A Herbelin, JM Gombert, A Vicari, M Papiernik and M Dy
IL-7 plays an important role in the growth and differentiation of T cells.
We have previously reported that IL-7 induces preferential expansion of MHC
class I-selected CD4-CD8-TCR alpha beta+ thymocytes which express a skewed
V beta repertoire and are potent IL-4 producers. In this report, we provide
evidence that IL-1 in combination with granulocyte macrophage colony
stimulating factor can also expand this population. Yet, these cells do not
share the functional characteristics of those obtained in the presence of
IL-7, i.e. cytotoxic activity and high IL-4 production. These functional
capacities can be acquired by adding IL-7. In conclusion, our findings
demonstrate that the capacity of MHC class I-selected CD4-CD8-TCR alpha
beta+ thymocytes to produce IL-4 as well as to kill target cells is IL- 7
dependent.
ARTICLES
Requirement of IL-7 for IL-4-producing potential of MHC class I- selected CD4-CD8-TCR alpha beta+ thymocytes
CNRS URA 1461, Universite Rene Doscartes-Paris V, France.
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