International Immunology, Vol. 7, No. 3, pp. 501-504,March 1995
© 1995 Japanese Society for Immunology
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CD4+ but not CD8+T cells are required for the induction of oral tolerance
Department of Immunology, Western Infirmary, University of Glasgow Glasgow G11 6NT, UK
Correspondence to: Correspondence to: P. Garside
It has been suggested that oral tolerance is mediated by CD8+ T lymphocytes, but the functional properties of these cells are unclear. Here we show that the induction of tolerance by feeding mice ovalbumin (OVA) does not prime antigen-specific class I MHC-restricted cytotoxic T cells in vivo. Indeed, such responses are markedly suppressed in mice fed OVA, and the induction of oral tolerance is abolished by depletion in vivo of CD4+ but not CD8+ T cells. These results indicate that CD8+ lymphocytes are unlikely to play a major role in the induction of oral tolerance and are the first demonstration that specific cytotoxic responses to an exogenous antigen can be suppressed by feeding antigen.
Keywords: CD4+, CD8+, cytotoxic T lymphocyte, oral tolerance
Received 15 September 1994, accepted 25 November 1994.
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