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International Immunology, Vol. 7, No. 3, pp. 415-423,March 1995
© 1995 Japanese Society for Immunology

Lymphoproliferative disorders in IL-7 transgenic mice: expansion of immature B cells which retain macrophage potential

A. G. Fisher, C. Burdet1, C. Bunce2, M. Merkenschlager and Rh. Ceredig1

MRC Lymphocyte Development Group, MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital Du Cane Road, London W12 0NN, UK
1 Laboratoire de Génétique Molèculaire des Eucaryotes, CNRS, Institut de Chimie Biologique, Faculté de Médecine 11 rue Humann, 67085 Strasbourg Cedex, France
2 Department of Immunology, University of Birmingham Medical School Vincent Drive, Edgbaston, Birmingham B15 2TJ, UK

Correspondence to: Correspondence to: A. G. Fisher

Transgenic mice carrying the murine IL-7 gene under the MHC class II (E{alpha}) promoter are described which develop lymphoid tumours at a high incidence when maintained in conventional or specific pathogen-free environments. Cells obtained from the lesions were relatively monomorphic, expressed a variety of B cell associated markers (BP-1, B220, CD43) but lacked surface Ig. Some mice showed expanded populations of cells phenotypically similar to the recently reported bipotent B/macrophage stem cell subset (AA4.1high, B220–, Ig–) which could be cloned and maintained in vitro. These cells expressed IL-7 receptors, proliferated in response to IL-7 and in most cases had germllne configuration of the Ig heavy chain locus. Cell lines cloned from two such tumours generated macrophages spontaneously in culture, consistent with their bipotent B cell/macrophage phenotype. These results suggest that IL-7 plays a role in very early stages of B cell ontogeny prior to bona fide B cell commitment.

Keywords: B cell, IL-7, lymphoproliferative disorder, macrophage

Received 6 September 1994, accepted 18 November 1994.


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