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International Immunology, Vol. 5, No. 9, pp. 1183-1190,September 1993
© 1993 Japanese Society for Immunology

IL-5 receptor positive B cells, but not eosinophils, are functionally and numerically influenced in mice carrying the X-linked immune defect

Yasumichi Hitoshi1,2,, Eiichiro Sonoda2, Yuji Kikuchi1,2, Shin Yonehara3, Hiromitsu Nakauchi4 and Kiyoshi Takatsu1,2

1 Department of Immunology, Institute of Medical Science, The University of Tokyo 4-6-1 Shirokanedai, Minato-ku, Tokyo 108, Japan
2 Department of Biology, Institute for Medical Immunology, Kumamoto University Medical School 2-2-1 Honjo, Kumamoto 860, Japan
3 Department of Biology, Tokyo Metropolitan Institute of Medical Science 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113, Japan
4 Riken Research Institute Tsukuba-shi, Ibaraki 305, Japan

Correspondence to: Correspondence to: Y. Hitoshi

Mouse IL-5 (mIL-5) acts on B cells and eosinophils to induce growth and differentiation through the mIL-5 specific receptor (mIL-5R). The functional high-affinity mIL-5R is a heterodimer composed of {alpha} and ß chains. We investigated the expression of mIL-5R and the responsiveness of B cells and eosinophils to mIL-5 In X-linked immunodeficient (xld) mice. mIL-5R expression analyzed by using mAbs specific for {alpha} and ß chains revealed that xld B cells had fewer mIL-5R{alpha}+mIL-5Rß+ than BALB/c B cells. In particular, a decrease in the number of peritoneal mIL-5R+ B cells among Ly-1 B cells (known as B-1 cells) was remarkable. Furthermore, the frequency of precursors of mIL-5 responsive B cells in xld mice was ~100-fold lower than that of BALB/c mice. Interestingly, sorted mIL-5R+ peritoneal B cells from xld mice displayed a low response to mIL-5. Intraperltoneal injection of mIL-5 into BALB/c mice induced polyclonal IgM production and an increase in the number of eosinophils. The same regimen failed to induce an increase in the same parameters in xld mice. However, xld mice showed mIL-5-induced eoslnophilla in peripheral blood to a similar extent as BALB/c mice. Eosinophils from mIL-5-injected xld mice expressed both {alpha} and ß chains of mIL-5, and responded to mlL-5 with prolonged in vitro survival.

Keywords: B-1 cells, B cell activation, eosinophil induction, IL-5, IL-5 receptor, peritoneal B cells, xid

Received 8 January 1993, accepted 19 April 1993.


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