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International Immunology, Vol. 5, No. 9, pp. 1177-1182,September 1993
© 1993 Japanese Society for Immunology

Influence of age on the signal transduction of T cells in mice

Masanori Utsuyama1, Zsuzsa Varga3, Kiyoko Fukami4, Yoshimi Homma2, Tadaomi Takenawa4 and Katsuiku Hirokawa1,

1 Department of pathology, Tokyo Metropolitan Institute of Gerontology 35-2, Sakaecho, Itabashi-ku, Tokyo, Japan
2 Department of Biosignals, Tokyo Metropolitan Institute of Gerontology 35–2, Sakaecho, Itabashi-ku, Tokyo, Japan
3 Department of Forensic Medicine, University Medical School Debrecen, Hungary
4 Department of department of Molecular Oncology, Institute of Medical Science, University of Tokyo Tokyo, Tokyo

Correspondence to: Correspondence to: K. Hirokawa

A 5- to 10-fold decline was observed in the proliferative activity of T cells stimulated with anti- CD3 mAb between young and old mice. However, the number of CD3 molecules on the T cell surface was almost comparable between young and old T cells. The formation of the second messenger such as inositol triphosphate (IP3) and dlacylglycerol (DAG) after mitogenic stimulation decreased in old T cells as compared with young ones. The activity of phospholipase C (PLC), which is responsible for the liberation of IP3 and DAG from phosphatidylinositol-4, 5- blsphosphate (PIP2 was not different between young and old T cells. The content of PIP2 in the membrane was also comparable between young and old T cells. These findings have suggested that the age-related decline in the prollferative activity of T cells could be due to impairment of intracellular signal transduction, probably in the pathway somewhere between TCR and PLC.

Keywords: diacylgylcerol, inositol phosphates, phospholipase C, second messengers

Received 18 March 1993, accepted 10 June 1993.


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