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International Immunology, Vol. 5, No. 9, pp. 1023-1033,September 1993
© 1993 Japanese Society for Immunology

The role of macrophages in antigen presentation and T cell tolerance

Toru Miyazaki2, Gen Suzuki1, and Ken-ichi Yamamura

Institute of Molecular Embryology and Genetics, Kumamoto University Medical School Kuhonji, Kumamoto 862, Japan
1 Division of Radiation Health, National Institute of Radiological Sciences Anagawa, Inage-ku, Chiba 263, Japan
2Present address: Laboratoire de Génétique Moleculaire des Eurkaryotes du CNRS Unité 184 de Biologie Moleculaire et de Génie Génétique de I'INSERM, Institut de Chimie Biologique, Faculté de Médecine rue Humann, 67085 Strasbourg Cedex, France

Correspondence to: Correspondence to: G. Suzuki

Bone marrow derived cells (dendritic cells, macrophages and B cells) are involved in antigen presentation and T cell tolerance. However, the precise functions of each cell type remain unclear. To determine the role of macrophages we produced transgenic mice expressing I-E molecules only on macrophages, by introducing the hybrid gene containing the colony stimulating factor-1 (CSF-1) receptor promoter region and the structural gene encoding E{alpha}d into C57BL/6 mice. In these mice I-E restricted antigen presentation and T cell priming were impaired. With respect to T cell tolerance, I-E reactive T cells were energized but not clonally deleted. These results clearly demonstrate that macrophages by themselves are defective in efficient I-E restricted antigen presentation, so that T cells exposed to antigens expressed on macrophages are led to anergy.

Keywords: c-fms, class II MHC, clonal anergy, macrophage, transgenic mouse

Received 5 April 1993, accepted 14 May 1993.


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