Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (59)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Berney, T.
Right arrow Articles by Izui, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Berney, T.
Right arrow Articles by Izui, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

International Immunology, Vol. 4, No. 1, pp. 93-99,January 1992
© 1992 Japanese Society for Immunology

Selective pathogenicity of murine rheumatoid factors of the cryoprecipitable IgG3 subclass

Thierry Berney, Thierry Fulpius, Takanori Shibata, Luc Reininger, Jacques Van Snick1, Hua Shan2, Martin Weigert2, Ann Marshak-Rothstein3 and Shozo Izui

Department of Pathology, Centre Médical Universitaire, University of Geneva 1211 Geneva 4, Switzerland
1 Ludwing Institute for Cancer Research Brussels, Belgium
2 Institute for Cancer Research, Fox Chase Cancer Center Philadelphia, PA 19111, USA
3 Department of Microbiology, Boston University Medical Center Boston, MA 02118, USA

Correspondence to: Correspondence to: S. lzui

To analyze the involvement of rheumatoid factors (RF) in the generation of cryoglobulins and the development of related tissue injuries, we have established a panel of anti-IgG2a RF mAbs derived from MRL/MpJ-lpr/lpr (MRL-lpr), C3H/HeJ-lpr/lpr, and 129/Sv mice. After injection of hybridoma cells to normal mice, all four IgG3 RF mAbs induced cryoglobullnemia, and various degrees of glomerulonephritis and skin leukocytoclastic vasculitis. In contrast, none of the RF mAbs of the other isotypes generated cryoglobulins or tissue lesions. Since the same observation was obtained with another panel of five clonally related anti-IgG2a RF mAbs of MRL-lpr origin with almost Identical heavy and light chain variable (V) regions but five different Isotypes, it seems unlikely that the absence of pathogenicity of non-IgG3 RF mAbs was due to differences in fine specificity or V framework regions. In addition, the analysis of serum RF In MRL-lpr mice has demonstrated that a majority of 4 month old MRL-lpr mice produced substantial amounts of IgG3 RF with cryoglobulin activity. Because the cryoglobulin activity is associated with the murine IgG3 heavy chain constant region, RF of this subclass may play a significant role in the development of autoimmune-related tissue injuries, especially In MRL-lpr mice.

Keywords: autoimmunity, glomerulonephritis, vasculitis, MRL-lpr/lpr

Received 9 September 1991, accepted 14 October 1991.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Immunol.Home page
M. Trendelenburg, L. Fossati-Jimack, J. Cortes-Hernandez, D. Turnberg, M. Lewis, S. Izui, H. T. Cook, and M. Botto
The Role of Complement in Cryoglobulin-Induced Immune Complex Glomerulonephritis
J. Immunol., November 15, 2005; 175(10): 6909 - 6914.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Kuroda, A. Kuroki, S. Kikuchi, T. Funase, M. Nakata, and S. Izui
A Critical Role for Sialylation in Cryoglobulin Activity of Murine IgG3 Monoclonal Antibodies
J. Immunol., July 15, 2005; 175(2): 1056 - 1061.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Moll, L. Nitschke, M. Carroll, J. V. Ravetch, and S. Izui
A Critical Role for Fc{gamma}RIIB in the Induction of Rheumatoid Factors
J. Immunol., October 1, 2004; 173(7): 4724 - 4728.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
L. Bao, M. Haas, D. M. Kraus, B. K. Hack, J. K. Rakstang, V. M. Holers, and R. J. Quigg
Administration of a Soluble Recombinant Complement C3 Inhibitor Protects Against Renal Disease in MRL/lpr Mice
J. Am. Soc. Nephrol., March 1, 2003; 14(3): 670 - 679.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Kikuchi, Y. Pastore, L. Fossati-Jimack, A. Kuroki, H. Yoshida, T. Fulpius, K. Araki, S. Takahashi, R. Lemoine, L. Reininger, et al.
A Transgenic Mouse Model of Autoimmune Glomerulonephritis and Necrotizing Arteritis Associated with Cryoglobulinemia
J. Immunol., October 15, 2002; 169(8): 4644 - 4650.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. Kuroki, Y. Kuroda, S. Kikuchi, F. Lajaunias, T. Fulpius, Y. Pastore, L. Fossati-Jimack, L. Reininger, T. Toda, M. Nakata, et al.
Level of galactosylation determines cryoglobulin activity of murine IgG3 monoclonal rheumatoid factor
Blood, April 15, 2002; 99(8): 2922 - 2928.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
T. Mizuochi, Y. Pastore, K. Shikata, A. Kuroki, S. Kikuchi, T. Fulpius, M. Nakata, L. Fossati-Jimack, L. Reininger, M. Matsushita, et al.
Role of galactosylation in the renal pathogenicity of murine immunoglobulin G3 monoclonal cryoglobulins
Blood, June 1, 2001; 97(11): 3537 - 3543.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
I. R. Rifkin, E. A. Leadbetter, B. C. Beaudette, C. Kiani, M. Monestier, M. J. Shlomchik, and A. Marshak-Rothstein
Immune Complexes Present in the Sera of Autoimmune Mice Activate Rheumatoid Factor B Cells
J. Immunol., August 1, 2000; 165(3): 1626 - 1633.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
L. Fossati-Jimack, A. Ioan-Facsinay, L. Reininger, Y. Chicheportiche, N. Watanabe, T. Saito, F. M. A. Hofhuis, J. E. Gessner, C. Schiller, R. E. Schmidt, et al.
Markedly Different Pathogenicity of Four Immunoglobulin G Isotype-Switch Variants of an Antierythrocyte Autoantibody Is Based on Their Capacity to Interact in Vivo with the Low-Affinity Fc{gamma} Receptor III
J. Exp. Med., April 17, 2000; 191(8): 1293 - 1302.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
L. Fossati-Jimack, L. Reininger, Y. Chicheportiche, R. Clynes, J. V. Ravetch, T. Honjo, and S. Izui
High Pathogenic Potential of Low-Affinity Autoantibodies in Experimental Autoimmune Hemolytic Anemia
J. Exp. Med., December 6, 1999; 190(11): 1689 - 1696.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
N. Watanabe, B. Akikusa, S. Y. Park, H. Ohno, L. Fossati, G. Vecchietti, J. E. Gessner, R. E. Schmidt, J. S. Verbeek, B. Ryffel, et al.
Mast Cells Induce Autoantibody-Mediated Vasculitis Syndrome Through Tumor Necrosis Factor Production Upon Triggering Fcgamma Receptors
Blood, December 1, 1999; 94(11): 3855 - 3863.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Tada, K. Nagasawa, A. Ho, F. Morito, S. Koarada, O. Ushiyama, N. Suzuki, A. Ohta, and T. W. Mak
Role of the Costimulatory Molecule CD28 in the Development of Lupus in MRL/lpr Mice
J. Immunol., September 15, 1999; 163(6): 3153 - 3159.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Wang and M. J. Shlomchik
Maternal Ig Mediates Neonatal Tolerance in Rheumatoid Factor Transgenic Mice but Tolerance Breaks Down in Adult Mice
J. Immunol., March 1, 1998; 160(5): 2263 - 2271.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
O. Chan and M. J. Shlomchik
A New Role for B Cells in Systemic Autoimmunity: B Cells Promote Spontaneous T Cell Activation in MRL-lpr/lpr Mice
J. Immunol., January 1, 1998; 160(1): 51 - 59.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
G. S. Gilkeson, J. S. Mudgett, M. F. Seldin, P. Ruiz, A. A. Alexander, M. A. Misukonis, D. S. Pisetsky, and J. B. Weinberg
Clinical and Serologic Manifestations of Autoimmune Disease in MRL-lpr/lpr Mice Lacking Nitric Oxide Synthase Type 2
J. Exp. Med., August 4, 1997; 186(3): 365 - 373.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
M.-L. Santiago, L. Fossati, C. Jacquet, W. Muller, S. Izui, and L. Reininger
Interleukin-4 Protects against a Genetically Linked Lupus-like Autoimmune Syndrome
J. Exp. Med., January 6, 1997; 185(1): 65 - 70.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
F. Furukawa
Animal models of cutaneous lupus erythematosus and lupus erythematosus photosensitivity
Lupus, January 1, 1997; 6(2): 193 - 202.
[PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.