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International Immunology, Vol. 4, No. 1, pp. 75-82,January 1992
© 1992 Japanese Society for Immunology

Clonal elimination of self reactive Vß6+ T cells induced by H-2 products expressed on thymic radio-resistant components

Hisashi Arase, Noriko Arase, Kazumasa Ogasawara, Robert A. Good1 and Kazunori Onoé

Institute of Immunological Science, Hokkaido University Sapporo 060, Japan
1 All Children's Hospital, University of South Florida St Petersburg, FL 33701, USA

Correspondence to: Correspondence to: K. Onoè

The role of thymic radio-resistant cells on clonal elimination of Vß6+ T cells that are reactive to minor lymphocyte stimulatory (Mls)-1a plus I-E antigens has been investigated. Previous studies with allogeneic bone marrow chimeras revealed that radio-sensitive I-E+ cells derived from donor bone marrow in the thymus play a major role in the clonal elimination of Vß6+ T cells. However, we could show that not only the thymic bone marrow derived components but also the radio-resistant ones (presumably thymic epithelial cells) might be involved in induction of clonal elimination of the self-reactive T cells. The proportion of Vß6+ T cells present varied with the H-2 haplotype of the thymus and the cell types presenting Mls-1a products, which might be attributable to differences in the affinity of the H-2 products to T cell antigen receptors and differences In the amount of tolerogens expressed on the stromal cells.

Keywords: T cell tolerance, thymic epithelial cells, T cell antigen receptor, minor lymphocyte stimulatory antigens

Received 5 September 1991, accepted 9 October 1991.


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