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International Immunology, Vol. 4, No. 1, pp. 101-105,January 1992
© 1992 Japanese Society for Immunology

other

Mechanisms of induction of tolerance to syngeneic IgE

Seiji Haba and Alfred Nisonoff

Rosenstiel Research Center, Department of Biology, Brandeis University Waltham, MA 02254, USA

Correspondence to: Correspondence to: S. Haba

We have previously shown that T cell tolerance to syngeneic IgE in mice is delayed after birth for 2–3 weeks and is Induced concurrently with the appearance of IgE in serum. Although inoculation of IgE in saline on the day of birth caused T cell tolerance, an apparent Inconsistency was our Inability to tolerize mice after day 2, despite evidence indicating that endogenously-produced IgE is effective at the age of 2–3 weeks. Data presented here indicate that repeated I.p. inoculations, during this period, of smaller doses of IgE in saline induce tolerance in many Individual mice, thus mimicking to a degree the naturally occurring events. Another earlier finding was that normal adult B cells, but not T cells, can tolerize T cells to IgE when administered on the day of birth. We have now observed that B cells bearing surface IgE are much more tolerogenic than the remaining B cells.

Keywords: tolerance, autoimmunity, IgE, autoantibodies

Received 4 September 1991, accepted 13 September 1991.


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