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International Immunology, Vol. 3, No. 2, pp. 141-148,February 1991
© 1991 Japanese Society for Immunology

Novel pathways of antigen presentation for the maintenance of memory

David Gray, Marie Kosco and Brigitta Stockinger

Basel Institute for Immunology Grenzacherstrasse 487, Postfach CH 4005, Basel, Switzerland

Correspondence to: Correspondence to D. Gray

Follicular dendritic cells (FDC) store native antigen for long periods In tymphoid follicles and so provide a source ofcontinued stimulation for specific B cells. The expression of MHC class II by FDC suggested they might act as antigen-presenting cells for MHC class ll-restricted T cells. We show here, however, that the MHC class II molecules found on their surface are not synthesized by the FDC but are picked up from surrounding B cells In germinal centres. Although FDC by themselves cannot present native antigen to T cells, acquired MHC class ll-peptlde complexes can be recognized by T cells. The true physiological role of FDC seems to be as long-term antigen depots. We demonstrate that antigen localized onto FDC In vivo can be retrieved by antigen-specific B cells, which In turn process and present It to T cells. Thesepresentation pathways are likely to be crucial In both the maintenance of long-term Immune responses and the continued survival of memory cells.

Keywords: follicular dendritic cells, memory B cells, memory T cells, germinal centers, MHC class II, antigen transfer

Received 31 August 1990, accepted 1 November 1990.


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