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International Immunology, Vol. 3, No. 11, pp. 1189-1192,November 1991
© 1991 Japanese Society for Immunology

other

TCF-1, a T cell-specific transcription factor of the HMG box family, interacts with sequence motifs in the TCRß and TCR{delta} enhancers

Mariëtte A. Oosterwegel, Marc L. van de Wetering, Frank C. P. Holstege, Haydn M. Prosser1, Michael J. Owen1 and Hans C. Clevers

Department of Clinical Immunology, University Hospital Utrecht PO Box 85500, 3508 GA Utrecht, The Netherlands
1 Imperial Cancer Research Fund, St Bartholomew's Hospital, Dominion House 59 Bartholomew Close, London EC1A 7BE, UK

Correspondence to: Correspondence to: H. C. Clevers

We have recently identified and cloned TCF-1, a T cell-specific transcription factor with specificity for the AACAAAG motif in the CD3erDotenhancer and for the TTCAAAG motif in the TCR{alpha} enhancer. TCF-1 belongs to the family of transcription-regulating proteins which share a region of homology termed the HMG-box. Here, we show by gel retardation analysis that TCF-1 specifically recognizes the Tß5 element of the TCRß enhancer and the T{delta}7 element of the TCR{delta} enhancer. Comparison of the sequences of all elements recognized by TCF-1 defines a consensus motif A/T A/T C A A/G A G. These observations imply that TCF-1 is involved in the control of several T cell-specific genes and might thus play an important role in the establishment and maintenance of the mature T cell phenotype.

Keywords: TCR-CD3 genes, TCF-1{alpha}

Received 20 May 1991, accepted 2 August 1991.


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