Skip Navigation


International Immunology Advance Access originally published online on February 26, 2009
International Immunology 2009 21(4):313-316; doi:10.1093/intimm/dxp016
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
21/4/313    most recent
dxp016v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Int. Immunol.
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Kaisho, T.
Right arrow Articles by Takeda, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kaisho, T.
Right arrow Articles by Takeda, K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


© The Japanese Society for Immunology. 2009. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

review-article

The study of innate immunity in Japan: a historical perspective

Tsuneyasu Kaisho1 and Kiyoshi Takeda2,3

1 Laboratory for Host Defense, RIKEN Research Center for Allergy and Immunology, 1-7-22, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
2 Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University
3 World Premier International Immunology Frontier Research Center, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan

Correspondence to: T. Kaisho; E-mail: tkaisho{at}rcai.riken.jp, K. Takeda; E-mail: ktakeda{at}ongene.med.osaka-u.ac.jp

Innate immunity is key for host defense in a vast range of organisms, from invertebrates to vertebrates. A number of Japanese scientists have made significant contributions to the clarification of innate immune mechanisms and have applied this knowledge to treatments for various diseases including cancer, allergy and autoimmune disorders. Here, we present an overview of the development of innate immunology by highlighting several Japanese contributors.

Keywords: antigen-presenting cell, CpG DNA, lipopolysaccharide, phagocytes, Toll-like receptor

Received 26 January 2009, accepted 30 January 2009.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?

Related articles in Int. Immunol.:

The roles of TLRs, RLRs and NLRs in pathogen recognition
Taro Kawai and Shizuo Akira
Int. Immunol. 2009 21: 317-337. [Abstract] [FREE Full Text]  



This article has been cited by other articles:


Home page
 Int ImmunolHome page
T. Takai and H. Karasuyama
The study of allergy by Japanese researchers: a historical perspective
Int. Immunol., December 1, 2009; 21(12): 1311 - 1316.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.