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International Immunology Advance Access originally published online on January 30, 2009
International Immunology 2009 21(3):295-301; doi:10.1093/intimm/dxn148
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© The Japanese Society for Immunology. 2009. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Differential regulation of splenic CD8– dendritic cells and marginal zone B cells by Notch ligands

Chiyoko Sekine1, Yuko Moriyama1, Akemi Koyanagi2, Noriko Koyama1,3, Hideko Ogata1, Ko Okumura1 and Hideo Yagita1

1 Department of Immunology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
2 Division of Cell-Biology, Bio-medical Research Center, Juntendo University School of Medicine, Tokyo, Japan
3 Probiotics Research Laboratory, Juntendo University School of Medicine, Tokyo, Japan

Correspondence to: C. Sekine; E-mail: csekine{at}med.juntendo.ac.jp

The importance of Notch signaling to maintain CD8– dendritic cells (DCs) in the spleen has recently been revealed. However, the ligand responsible for this Notch signaling has not been determined yet. In this study, we demonstrated that blocking of Delta-like (Dll) 1 alone had no significant effect on the maintenance of CD8– DCs while marginal zone (MZ) B cells were significantly reduced in the spleen of mice. On the other hand, blocking of Dll1, Dll4, Jagged1 and Jagged2 significantly decreased CD8– DCs. All these Notch ligands are expressed predominantly in the red pulp of the spleen where CD8– DCs reside. These results indicate a differential regulation of CD8– DCs and MZ B cells by Notch ligands in the spleen.

Keywords: Delta-like 1, dendritic cells, marginal zone B cells, Notch

Transmitting editor: T. Watanabe

Received 25 September 2008, accepted 24 December 2008.


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