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International Immunology Advance Access originally published online on September 17, 2009
International Immunology 2009 21(11):1205-1211; doi:10.1093/intimm/dxp096
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© The Japanese Society for Immunology. 2009. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

review-article

Morbus Crohn—a disease of failing macroautophagy in the immune system?

Sonja Meixlsperger and Christian Münz

Viral Immunobiology, Institute of Experimental Immunology, University Hospital of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland

Correspondence to: C. Münz; E-mail: christian.muenz{at}usz.ch

Mutations in genes involved in macroautophagy have been found to be associated with Morbus Crohn, also called Crohn's disease (CD), an inflammatory bowel disease. Taking this disease as an example for pathogenesis due to altered macroautophagy, we discuss here how macroautophagy supports innate and adaptive immunity. This support ranges from maintenance of components of the immune system, antigen processing for presentation to the immune system, to education of the immune system in order to distinguish self from dangerous non-self. A better understanding of these mechanisms should allow us not only to develop therapeutical strategies for CD but also to utilize macroautophagy for enhanced immunity against pathogens and tumors.

Keywords: antigen presentation, Atg16L1, central tolerance, IRGM, macroautophagy, NOD2, Paneth cells, T cells, Toll-like receptors

Received 13 July 2009, accepted 2 September 2009.


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