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International Immunology Advance Access originally published online on September 7, 2009
International Immunology 2009 21(10):1101-1103; doi:10.1093/intimm/dxp091
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© The Japanese Society for Immunology. 2009. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

review-article

The study of regulatory T cells and NKT cells in Japan: a historical perspective

Hisashi Arase1,2 and Ken-ichiro Seino3,4

1 Laboratory of Immunochemistry, World Premier International Immunology Frontier Research Center
2 Department of Immunochemistry, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0081, Japan
3 Division of Bioregulation Research, Institute of Medical Science, St Marianna University Graduate School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki-City, Kanagawa 216-8511, Japan
4 Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan

Correspondence to: K.-i. Seino; E-mail: seino{at}marianna-u.ac.jp, and H. Arase; E-mail: arase{at}biken.osaka-u.ac.jp

Immune regulation plays an important role in maintaining homeostasis of the immune system. A number of Japanese immunologists have made significant contributions to the elucidation of the mechanisms of immune regulation. In particular, lymphocyte populations that could regulate immune responses—for example regulatory T cells and NKT cells—have been extensively analyzed. Here, we present an overview of research on immune regulation by highlighting the work of several Japanese contributors.

Keywords: NKT cells, regulatory T cells, suppressor T cells

Received 21 May 2009, accepted 20 August 2009.


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