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International Immunology Advance Access originally published online on June 10, 2008
International Immunology 2008 20(8):949-960; doi:10.1093/intimm/dxn054
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© The Japanese Society for Immunology. 2008. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

CD83 regulates splenic B cell maturation and peripheral B cell homeostasis

Katja Lüthje1, Birte Kretschmer1, Bernhard Fleischer1,2 and Minka Breloer1

1 Department of Immunology, Bernhard-Nocht-Institute for Tropical Medicine, Bernhard-Nocht-Strasse 74, 20359 Hamburg, Germany
2 Institute for Immunology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany

Correspondence to: M. Breloer; E-mail: breloer{at}bni-hamburg.de

The central function of murine CD83 that is expressed on thymic epithelial cells is to induce the progression of double-positive thymocytes to single CD4-positive T cells. Several lines of evidence suggest an additional role for CD83 in the regulation of peripheral T and B cell responses. Here we show that CD83 is expressed by immature B cells and regulates their further maturation and survival in the periphery. Employing mixed bone marrow chimeras, we compare wild-type, CD83 over-expressing and CD83-deficient B cells within the same host. CD83 over-expression on the immature B cells themselves led to an accumulation of transitional B cells and a reciprocally reduced maturation of follicular B cells that was strictly correlated to the intensity of CD83 over-expression. The absence of CD83 on B cells resulted in a decreased maturation of marginal zone B cells and conferred a mild selection advantage for B cell survival in the periphery. Consenting with these findings, the over-expression of CD83 specifically and dose dependently interfered with homeostasis of B cells while T cell survival was not affected by CD83 over-expression over a period of 30 weeks. Taken together, our data suggest that CD83 negatively regulates B cell maturation and survival.

Keywords: B cell homeostasis, B cell maturation, CD83, transgenic mice

Transmitting editor: M. Reth

Received 2 January 2008, accepted 9 May 2008.


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B. Kretschmer, K. Luthje, S. Schneider, B. Fleischer, and M. Breloer
Engagement of CD83 on B Cells Modulates B Cell Function In Vivo
J. Immunol., March 1, 2009; 182(5): 2827 - 2834.
[Abstract] [Full Text] [PDF]


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