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International Immunology Advance Access originally published online on November 13, 2007
International Immunology 2008 20(1):39-44; doi:10.1093/intimm/dxm118
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© The Japanese Society for Immunology. 2007. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Testis-expressed protein TSGA10 – an auto-antigen in autoimmune polyendocrine syndrome type I

Koit Reimand1, Jaakko Perheentupa2, Maire Link1, Kai Krohn3, Pärt Peterson1 and Raivo Uibo1

1 Immunology and Molecular Pathology Groups, Centre of Molecular and Clinical Medicine, University of Tartu, 19 Ravila Street, Tartu 50411, Estonia
2 Hospital for Children and Adolescents, University of Helsinki, Helsinki FIN-00290, Finland
3 Institute of Medical Technology, University of Tampere, Tampere FIN-33014, Finland

Correspondence to: R. Uibo; E-mail: raivo.uibo{at}ut.ee

Autoimmune polyendocrine syndrome type 1 (APS1) is a rare monogenic autosomal recessive disorder. Autoimmune gonadal failure is often one of its features. The aim of this study was to identify targets of immune reactions associated with male autoimmune hypogonadism in APS1. Human testis cDNA expression library immunoscreening with APS1 patients' sera identified the protein testis-specific protein 10 (TSGA10), which is a testis-expressed protein with a key role in spermatogenesis. The corresponding serum autoantibodies were detected by Radioimmunoprecipitation assay in 3 of 40 male (7.5%) and 2 of 26 female (7.7%) APS1 patients but in none of either 32 patients with Addison's disease or 116 healthy controls (p = 0.0055). However, the TSGA10 antibodies in APS1 patients showed no correlation with testicular or ovarian failure or with autoimmune hypogonadism markers. Nevertheless, their presence in a proportion of patients with APS1 highlights the role of TSGA10 as a target of immune reactions in APS1.

Keywords: APECED, APS1, cDNA library

Transmitting editor: A. Cooke

Received 16 March 2007, accepted 15 October 2007.


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