International Immunology, Vol. 2, No. 3, pp. 201-207,March 1990
© 1990 Japanese Society for Immunology
The immunoglobulin 
-like gene cluster (14.1, 16.1, and F1) contains gene(s) selectively expressed in pre-B cells and is the human counterpart of the mouse 5 gene
Centre d'Immunologie INSERM-CNRS de Marseille-Luminy Case 906, 13288 Marseille Cedex 9, France
1 Laboratorie d'lmmunogénétique, UA CNRS 1191, Université des Sciences et Techniques du Languedoc 34060 Montpellier Cedex, France
2 Unité INSERM U 108, Hò;pital Saint-Louis 1, Avenue Claude Vellefaux, 75010 Paris, France
Correspondence to: Correspondence to. Claudine Schiff, as above
A human immunoglobulin (Ig)-related gene, covering –8 kb, was Isolated from a cosmid genomic library, by hybridization with a C
probe and with a -like probe. This gene was Identified as 14.1. It belongs to the human -like cluster which is composed of three genes (14.1, 16.1 and F1) that do not rearrange. Sequence data indicate that 14.1 is organized similarly to the mouse 5 gene. It contains three exons with lengths of 69, 38, and 106 codons as compared with 65, 38, and 106 for exons 1, 2, and 3 of mouse 5, respectively. The corresponding homology values were 61, 66 and 75.5%. Using a 14.1 specific probe containing exon 1, we showed that this gene was selectively expressed in human pre-B cell lines. It is likely to encode a 213-amlno acid -like light chain that would associate with µ chains and play an Important role in the early steps of B cell differentiation.
Keywords: early Ig gene expression, human B cell ontogeny
Received 16 September 1989, accepted 4 December 1989.
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