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International Immunology, Vol. 2, No. 2, pp. 189-192,February 1990
© 1990 Japanese Society for Immunology

other

The unique nucleotide sequence of the Aß gene in the NOD mouse is shared with its nondiabetic sister strains, the ILI and the CTS mouse

T. O. Yoshida and Y. Koide

Department of Microbiology and Immunology, Hamamatsu University School of Medicine 3600 Handa-cho, Hamamatsu 431-31, Japan

Correspondence to: Correspondence to. Y Koide, as above

It is generally held that one of the recessive genes controlling diabetes in the NOD mouse is linked to the major histocompatibility complex (MHC). Unique substitution of Asp57 with Ser in the Aß chain is considered to make the Aß gene the MHC-llnked susceptibility gene. We therefore analysed the nucleotide sequences of the Aß second exon in ILI, CTS, and NON mice, which are nondiabetic inbred strains but are derived from the same Jcl-ICR mice as the NOD mouse. The DNA sequence analyses revealed that the Aß second exon sequences In the ILl and CTS mice, but not in the NON mouse, are identical to that of the NOD mouse. Possible roles of Ser57 of the Aß chain in the nondiabetic sister strains are discussed.

Keywords: Aß gene, nucleotide sequence, insulin-dependent diabetes mellitus, ILI mouse, CTS mouse, NOD mouse

Received 31 August 1989, accepted 17 November 1989.


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