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International Immunology, Vol. 2, No. 2, pp. 151-155,February 1990
© 1990 Japanese Society for Immunology

Bypass by an alternate ‘carrier’ of acquired unresponsiveness to hCG upon repeated immunization with tetanus-conjugated vaccine

Amitabh Gaur, K. Arunan, O. Singh and G. P. Talwar

National Institute of Immunology New Delhi 110067, India

Correspondence to: 1Present address: Department of Medicine, Division of Immunology and Rheumatology, Stanford University Medical School, Stanford, CA 94305, USA

Correspondence to: Correspondence to. Dr Amitabh Gaur, Department of Medicine, Division of Immunology and Rheumatology, Stanford University Medical School, Stanford, CA 94305, USA

We report here the use of an alternative cariler diphtheria toxoid (DT) In human subjects to overcome antigen-specific unresponsiveness upon Immunization with a hapten/ligand-carrier conjugate. In the phase I clinical trial of a birth control vaccine using gonadotrophin subunits linked to tetanus toxoid, some of the subjects failed to evoke a booster antibody response to human chorlonic gonadotrophin (hCG). Presentation of the ligand on DT Instead In subsequent Immunizations restored anti-hCG response.

Keywords: birth control vaccine, diphtheria toxoid, hCG, immune-unresponsiveness

Received 12 September 1989, accepted 7 November 1989.


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