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International Immunology, Vol. 2, No. 11, pp. 1117-1119,November 1990
© 1990 Japanese Society for Immunology

CD3{zeta} and {eta} chains are produced by alternative splicing from a common gene

Hiroshi Ohno and Takashi Saito

Division of Molecular Genetics, Center for Neurobiology and Molecular Immunology, School of Medicine, Chiba University Chiba 280, Japan

Correspondence to: Correspondence to T. Saito

We have analyzed the genomlc organization of the murlne CD3{eta} gene. As suggested from the sequence of CD3{eta} cDNA, exons I-VII are identical to those of CD3{zeta} and exon VIII Is a unique exon for CD3{eta}. Exon VIII of the CD3{eta} gene is located 4 kb downstream of exon VIII of the CD3{zeta} gene. Together with the existence of a splicing acceptor site Just before exon VIII of the CD3{eta} gene, the CD3{eta} chain Is proved to be produced by an alternatively spliced transcript of the common gene of CD3{zeta} and {eta}. Since T cell receptor complex contains two forms of {zeta} dimers, {zeta}-{zeta} and {zeta}- {eta}, on a single T cell, which seem to have different functions, the results Indicate the importance of analyzing the regulation of the alternative splicing to understand T cell function.

Keywords: CD3{zeta}, CD3{eta}, genomic organization, alternative splicing

Received 28 August 1990, accepted 5 September 1990.


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