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International Immunology, Vol. 2, No. 11, pp. 1063-1071,November 1990
© 1990 Japanese Society for Immunology

Murine suppressor T cell clones specific for minor histocompatibility antigens express CD4, CD8, and {alpha}ß T cell receptor molecules

Navreet K. Nanda, Elizabeth Thomson and Ivor Mason1

ICRF Tumour Immunology Unit, Department of Biology, Medawar Building, University College London Gower Street, London WC1E 6BT, UK
1 Neuroimmunology Programme, Department of Biology, Medawar Building, University College London Gower Street, London WC1E 6BT, UK

Correspondence to: Correspondence to (present address): N. K. Nanda, Department of Microbiology and Molecular Genetics, 5304 Life Sciences, University of California, Los Angeles, CA 90024, USA

We have been able to establish stable, minor histocompatibility antigen-specific, non-cytolytic, MHC-class ll-restricted suppressor T cell clones and lines. These suppressor T cells rearrange, transcribe, and express {alpha}ß T cell receptor. An unusual feature of all our clones and lines is the co-expression of CD4 and CD8 molecules on their cell surface, a characteristic which may distinguish them from conventional helper and cytolytic T cells in this system. The fact that multiple, phenotyplcally and functionally Identical cell lines were reproducibly obtained from this system indicates that antigen-specific down-regulation of Immune functions In certain circumstances Is mediated by T cells that are neither conventional cytolytic nor helper T cells.

Received 13 July 1990, accepted 13 August 1990.


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