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International Immunology 2007 19(8):913-921; doi:10.1093/intimm/dxm049
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© The Japanese Society for Immunology. 2007. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Selective suppression of Th2-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists

Akio Mori1, Koji Ogawa1,2, Koichiro Someya3, Yuichi Kunori3, Daisuke Nagakubo4, Osamu Yoshie4, Fujiko Kitamura5, Takachika Hiroi5 and Osamu Kaminuma1,2,5

1 Clinical Research Center for Allergy and Rheumatology, National Sagamihara Hospital, 18-1 Sakuradai, Sagamihara, Kanagawa 228-8522, Japan
2 Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd, Toda, Saitama 335-8505, Japan
3 Pharmaceutical Discovery Research Laboratories, Institute for Biomedical Research, Teijin Pharma Ltd, Hino, Tokyo 191-8512, Japan
4 Department of Microbiology, Kinki University School of Medicine, Osaka-Sayama, Osaka 589-8511, Japan
5 Department of Allergy and Immunology, Tokyo Metropolitan Institute of Medical Science, Bunkyo-ku, Tokyo 113-8613, Japan

Correspondence to: A. Mori; E-mail: mori-kkr{at}umin.ac.jp

The effects of selective CC chemokine receptor (CCR)-3 antagonists on antigen-induced leukocyte accumulation in the lungs of mice adoptively transferred with in vitro-differentiated Th1 and Th2 were investigated. Inhalation of antigen by mice injected with Th1 and Th2 initiated the migration of T cells themselves into the lungs. Subsequently, neutrophils massively accumulated in Th1-transferred mice, whereas eosinophil infiltration was specifically induced by Th2. CCR3 antagonists, SB-297006 and/or SB-328437, suppressed antigen-induced accumulation of Th2 as well as eosinophils in the lungs, whereas they failed to affect Th1-mediated airway inflammation. Not only Th2 and eosinophil infiltration but also cellular mobilization in Th1-transferred mice was attenuated by an anti-CC chemokine ligand-11 antibody. CCR3 antagonists reduced chemokine production in the lungs of mice transferred with Th2 but not Th1, suggesting that down-regulation of chemokine synthesis is involved in the selective inhibition of Th2-mediated eosinophil infiltration by CCR3 antagonists.

Keywords: asthma, chemokine, mouse, T cell

Transmitting editor: M. Miyasaka

Received 10 January 2007, accepted 29 March 2007.


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