International Immunology Advance Access originally published online on April 19, 2007
International Immunology 2007 19(5):621-626; doi:10.1093/intimm/dxm027
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The 14-bp deletion polymorphism in the HLA-G gene displays significant differences between ulcerative colitis and Crohn's disease and is associated with ileocecal resection in Crohn's disease
1 Chirurgische Klinik und Poliklinik–Innenstadt
2 Poliklinik für Zahnerhaltung und Parodontologie, Klinikum der Universität München, Munich, Germany
3 Klinik für Allgemeine Innere Medizin, Inselspital Bern, Bern, Switzerland
4 Medizinische Klinik–Innere Medizin, Knappschaftskrankenhaus Dortmund, Dortmund, Germany
5 Abteilung für Humangenetik, Ruhr-Universität Bochum, Bochum, Germany
6 Department Biologie II, Anthropologie und Humangenetik, Ludwig-Maximilians-Universität München, Munich, Germany
Correspondence to: J. Glas; E-mail: juergen.glas{at}med.uni-muenchen.de
HLA-G is a non-classical MHC class Ib molecule predominantly expressed in cytotrophoblasts and under pathological conditions also in chronically inflamed and in malignant tissues. Recently an increased expression of HLA-G was found in ulcerative colitis (UC), but not in Crohn's disease (CD). The HLA-G gene is located in IBD3, a linkage region for inflammatory bowel disease (IBD). A 14-bp deletion polymorphism (Del+/Del–) within exon 8 of the HLA-G gene might influence transcription activity and is therefore of potential functional relevance. To investigate whether the 14-bp deletion polymorphism is associated with IBD, 371 patients with CD, 257 patients with UC and 739 controls were genotyped. The heterozygous genotype (P = 0.031) and the Del+ phenotype (P = 0.038) were significantly increased, whereas the homozygous Del– phenotype (P = 0.038) was significantly decreased in UC when compared with CD. Thus, the 14-bp deletion polymorphism within the HLA-G gene displayed significant differences between UC and CD. Moreover, a significant increase of the Del+ allele (P = 0.002) and the Del+/Del+ genotype (P = 0.013) and a consecutive decrease of the Del–/– genotype (P = 0.024) were observed in those CD cases positive for ileocecal resection. Thus, a potential effect of the HLA-G gene in IBD may affect both UC and CD. Other polymorphisms linked to the 14-bp deletion polymorphism might also contribute to immunopathogenesis. As there are several partly functional polymorphisms within the promoter region potentially influencing HLA-G expression, further studies in IBD are necessary in the context of differential expression of HLA-G between UC and CD.
Keywords: Crohn's disease, HLA-G, inflammatory bowel disease, major histocompatibility complex, ulcerative colitis
Transmitting editor: A. Falus
Received 22 November 2006, accepted 22 February 2007.
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