International Immunology Advance Access originally published online on October 20, 2007
International Immunology 2007 19(12):1319-1327; doi:10.1093/intimm/dxm103
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Distinct gut-derived lactic acid bacteria elicit divergent dendritic cell-mediated NK cell responses
1 Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, Kongens Lyngby, Denmark
2 Laboratory of Immunology, Istituto Nazionale per la Ricerca sul Cancro (IST), Genoa, Italy
3 Laboratory of Immunology and Biotherapy, Department of Human Pathology, University of Messina, Messina, Italy
4 Present address: Novo Nordisk A/S, DK-2880, Bagsværd, Denmark
Correspondence to: L. N. Fink; E-mail: lnf{at}biocentrum.dtu.dk
Lactic acid bacteria (LAB) are abundant in the gastrointestinal tract where they continuously regulate the immune system. NK cells are potently activated by dendritic cells (DCs) matured by inflammatory stimuli, and NK cells are present in the gut epithelium and in mesenteric lymph nodes, but it is not known how NK–DC interactions are affected by the predominantly non-pathogenic LAB. We demonstrate that human DCs exposed to different strains of gut-derived LAB consistently induce proliferation, cytotoxicity and activation markers in autologous NK cells. On the contrary, strains of LAB differ greatly in their ability to induce DC-dependent IFN-
production by NK cells. This suggests that DCs stimulated by gut LAB may expand the pool of NK cells and increase their cytotoxic potential. Specific LAB, inducing high levels of IL-12 in DCs, may promote amplification of a type-1 response via potent stimulation of IFN- production in NK cells. Combining IFN--inducing and non-inducing LAB completely abrogates DC-mediated IFN- production by NK cells, and therefore LAB modulating IFN- production in NK cells may be important regulators of the immune response.
Keywords: cytokines, cytotoxicity, intestinal bacteria, probiotics
* These authors contributed equally to this study.
Transmitting editor: L. Moretta
Received 22 April 2007, accepted 20 September 2007.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  I. Sekirov and B. B. Finlay The role of the intestinal microbiota in enteric infection J. Physiol., September 1, 2009; 587(17): 4159 - 4167. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. T. Damsgaard, L. Lauritzen, P. C. Calder, T. R. Kjaer, and H. Frokiaer Reduced ex Vivo Interleukin-6 Production by Dietary Fish Oil Is Not Modified by Linoleic Acid Intake in Healthy Men J. Nutr., July 1, 2009; 139(7): 1410 - 1414. [Abstract] [Full Text] [PDF]
|
|