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International Immunology Advance Access originally published online on November 27, 2006
International Immunology 2007 19(1):81-92; doi:10.1093/intimm/dxl124
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© The Japanese Society for Immunology. 2006. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

The superantigen-induced polarization of T cells in rat peripheral lymph nodes is influenced by genetic polymorphisms in the IL-4 and IL-6 gene clusters

Ulrike Bode1,4, Marc Lörchner1, Reinhard Pabst1, Kurt Wonigeit2, Silke Overbeck3, Lothar Rink3 and Joachim Hundrieser2

1 Functional and Applied Anatomy, Medical School Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany
2 Center of Surgery, Medical School Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany
3 Institute of Immunology, RWTH University Aachen, Aachen, Germany
4 Present address: Anatomie II, OE 4120, Medizinische Hochschule Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany

Correspondence to: U. Bode; E-mail: bode.ulrike{at}mh-hannover.de

In recent years, it has become clear that the polarization of T cells depends on the genetic background. However, due to the complexity of the genetic background of each animal, a direct comparison of the phenotype is difficult. In this study, a new rat strain LEW.BN-4-10 carrying the chromosomal regions on chromosomes 4 and 10, which harbor IL-6 and IL-4 gene clusters of BN, has been bred on the genetic background of LEW. It was asked whether these two gene clusters influence the polarization of T cell responses. As a model, the Mycoplasma arthritidis mitogen (MAM)-induced inflammation was used focusing on the microenvironment of the draining lymph node (LN). The effect of differences in these regions was tested by comparing LEW.BN-4-10 and LEW rats under steady-state conditions and upon injection of MAM into the forepaw. Under steady-state conditions, the two strains showed differences in the dendritic cell (DC) subset composition. When MAM was injected, the number of T cells in LEW.BN-4-10 rats producing Th2 cytokines such as IL-4 and IL-13 was significantly increased compared with LEW. The data suggest that these differences in the microenvironments in LN of LEW and LEW.BN-4-10 rats resulted in different susceptibility to the disease (increase of cells in LN and paw swelling). In addition, deviations in the distribution and function of injected effector T cells were found in the LN of LEW and LEW.BN-4-10 rats after MAM treatment. The data indicate that the IL-6 and IL-4 gene clusters are involved in polarizing T cell responses in vivo.

Keywords: cytokines, dendritic cells, inflammation, lymph nodes, T cells

Transmitting editor: T. Hünig


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