International Immunology Advance Access originally published online on July 18, 2006
International Immunology 2006 18(9):1363-1373; doi:10.1093/intimm/dxl069
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Published by Oxford University Press 2006
Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia
1 Department of Translational Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA
2 Department of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA
3 Department of Antibody Technology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA
Correspondence to: A. G. Polson; E-mail: polson{at}gene.com
A new family of Ig domain receptors referred to as the immune receptor translocation-associated (IRTA) proteins, FcR homologs (FcRHs) or FcR-like that are expressed in lymphoid cells has been recently described. RNA expression analysis suggests that FcRH1–5/IRTA1–5 are expressed exclusively in subsets of the B-cell compartment. We generated mAbs to FcRH1–5/IRTA1–5 and examined their protein expression pattern in normal tissue and in chronic lymphocytic leukemia (CLL) cells. Our data indicated that FcRH1–5/IRTA1–5 were expressed in B-cell sub-populations; however, in some cases, the protein was not expressed in the same B-cell populations as suggested by the RNA expression analysis. FcRH1/IRTA5 was expressed throughout the B-cell lineage starting at the pro-B-cell stage but was down-regulated in plasma cells. FcRH2/IRTA4 was expressed preferentially in memory B cells. FcRH3/IRTA3 was expressed at low levels in naive, germinal center (GC) and memory B cells but was also expressed in NK cells. FcRH4/IRTA1 was expressed in a sub-population of memory B cells associated with mucosal tissue. FcRH5/IRTA2 was expressed in mature B cells and memory B cells and down-regulated in GC cells and, unlike all other B-cell-specific markers, maintained its expression in plasma cells from tonsil, spleen and bone marrow. We examined the expression of FcRH1–5/IRTA1–5 on the surface of CLL cells and found a similar pattern of expression on CLL cells as in the normal mature B cells, except for FcRH3/IRTA3 which was up-regulated in CLL.
Keywords: chronic lymphocytic leukemia, Fc receptor homologs, Fc receptor-like, FcRL, immunoreceptor translocation associated, memory B cells, NK cells
Transmitting editor: T. Tedder
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