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International Immunology Advance Access originally published online on June 23, 2006
International Immunology 2006 18(8):1337-1345; doi:10.1093/intimm/dxl066
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© The Japanese Society for Immunology. 2006. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Human germinal center T cells are unique Th cells with high propensity for apoptosis induction

Ekaterina Marinova, Shuhua Han and Biao Zheng

Department of Immunology, Baylor College of Medicine, M929, One Baylor Plaza, Houston, TX 77030, USA

Correspondence to: B. Zheng; E-mail: bzheng{at}bcm.tmc.edu

Collaborative interactions between Th cells and B cells are necessary for the production of antibody responses to most protein antigens and for the generation of memory B cells in germinal centers (GCs). Although it is well established that Th cells are pivotal for the GC reaction, the mechanisms that control the homeostasis of Th cells during the GC response remain largely unknown. Here we show that, unlike other effector T cells, a significant number of CD4+CD45RO+CD57+ T cells, which are the major Th cells residing in the GCs, are undergoing apoptosis in vivo. CD4+CD45RO+CD57+ GC T cells exhibit similar sensitivities to apoptotic signals and to caspase inhibitors as immature thymocytes. Moreover, CD4+CD45RO+CD57+ GC T cells express a unique profile of genes that control apoptosis and cell cycle, providing possible molecular mechanisms for the high rates of apoptotic death of these Th cells in the GCs.

Keywords: apoptosis, germinal center, helper T cells

Transmitting editor: D. Tarlinton


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This article has been cited by other articles:


Home page
 J. Immunol.Home page
E. Marinova, S. Han, and B. Zheng
Response to Comment on "Germinal Center Helper T Cells Are Dual Functional Regulatory Cells with Suppressive Activity to Conventional CD4+ T Cells"
J. Immunol., July 15, 2007; 179(2): 731 - 732.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Marinova, S. Han, and B. Zheng
Germinal Center Helper T Cells Are Dual Functional Regulatory Cells with Suppressive Activity to Conventional CD4+ T Cells
J. Immunol., April 15, 2007; 178(8): 5010 - 5017.
[Abstract] [Full Text] [PDF]


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