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International Immunology Advance Access originally published online on June 12, 2006
International Immunology 2006 18(8):1285-1293; doi:10.1093/intimm/dxl061
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© The Japanese Society for Immunology. 2006. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

CD4 T cells inhibit the CD8 T cell response during low-dose virus infection

Stephen Cose1, Clair Brammer, David J. Zammit, DA Blair and Leo Lefrançois

Division of Immunology, Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
1 Present address: School of Clinical Veterinary Science, University of Bristol, Langford, BS40 5DU, UK

Correspondence to: S. Cose; E-mail: s.cose{at}bristol.ac.uk

CD4 T cells are not thought to play a significant role in generating an effective primary CD8 T cell response to most viral infections. We have challenged this view by demonstrating that antigen-specific CD4 T cells can indeed suppress the proliferation of antigen-specific naive CD8 T cells in response to low doses of vesicular stomatitis virus. This finding is in contrast to the established observations that at high antigen loads CD4 T cells play little role in generating CD8 T cell responses, and that in non-infectious model systems CD4 T cells actually help the CD8 T cell response. Our results suggest that at low infectious doses, CD4 T cells play a much larger role in controlling infections than previously appreciated.

Keywords: CD4 T cells, cellular immunology, immune responses, vesicular stomatitis virus

Transmitting editor: S. Hedrick


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 Proc. Natl. Acad. Sci. USAHome page
D. A. Blair and L. Lefrancois
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PNAS, September 18, 2007; 104(38): 15045 - 15050.
[Abstract] [Full Text] [PDF]


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