International Immunology Advance Access originally published online on May 23, 2006
International Immunology 2006 18(7):991-1000; doi:10.1093/intimm/dxl044
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
review-article |
Emerging possibilities in the development and function of regulatory T cells
1 Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Shogoin 53, Kawahara-cho, Sakyoku, Kyoto 606-8507, Japan
2 Core Research for Evolutional Science and Technology (CREST) Program, Japan Science and Technology Agency, Kawaguchi 332-0012, Japan
Correspondence to: K. Wing; E-mail: kajsa{at}frontier.kyoto-u.ac.jp
CD25+CD4+ Regulatory T cells (Treg) represent a unique population of lymphocytes capable of powerfully suppressing immune responses. A large body of experimental data have now confirmed the essential role played by these cells in a host of clinically relevant areas such as self-tolerance, transplantation, allergy and tumor/microbial immunity. Despite this mass of knowledge, significant gaps in our understanding of fundamental Treg biology remain, particularly regarding their development and mechanisms of suppression. In this review we attempt to highlight the current controversies and directions in which this exciting field is moving.
Keywords: adaptive regulatory T cell, CTLA-4, Foxp3, natural regulatory T cells, tolerance
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  E. Jasny, M. Eisenblatter, K. Matz-Rensing, K. Tenner-Racz, M. Tenbusch, A. Schrod, C. Stahl-Hennig, V. Moos, T. Schneider, P. Racz, et al. IL-12-Impaired and IL-12-Secreting Dendritic Cells Produce IL-23 upon CD154 Restimulation J. Immunol., May 15, 2008; 180(10): 6629 - 6639. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Razmara, B. Hilliard, A. K. Ziarani, Y. H. Chen, and M. L. Tykocinski CTLA-4{middle dot}Ig converts naive CD4+CD25- T cells into CD4+CD25+ regulatory T cells Int. Immunol., April 1, 2008; 20(4): 471 - 483. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Guo, M. H. Jang, K. Otani, Z. Bai, E. Umemoto, M. Matsumoto, M. Nishiyama, M. Yamasaki, S. Ueha, K. Matsushima, et al. CD4+CD25+ regulatory T cells in the small intestinal lamina propria show an effector/memory phenotype Int. Immunol., March 1, 2008; 20(3): 307 - 315. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Kagimoto, H. Yamada, T. Ishikawa, N. Maeda, F. Goshima, Y. Nishiyama, M. Furue, and Y. Yoshikai A regulatory role of interleukin 15 in wound healing and mucosal infection in mice J. Leukoc. Biol., January 1, 2008; 83(1): 165 - 172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zheng, R. Sharma, F. Gaskin, S. M. Fu, and S.-T. Ju A Novel Role of IL-2 in Organ-Specific Autoimmune Inflammation beyond Regulatory T Cell Checkpoint: Both IL-2 Knockout and Fas Mutation Prolong Lifespan of Scurfy Mice but by Different Mechanisms J. Immunol., December 15, 2007; 179(12): 8035 - 8041. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G.H.M. van Puijvelde, T. van Es, E.J.A. van Wanrooij, K.L.L. Habets, P. de Vos, R. van der Zee, W. van Eden, Th. J.C. van Berkel, and J. Kuiper Induction of Oral Tolerance to HSP60 or an HSP60-Peptide Activates T Cell Regulation and Reduces Atherosclerosis Arterioscler. Thromb. Vasc. Biol., December 1, 2007; 27(12): 2677 - 2683. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Fujita, Y. Sato, K. Sato, K. Eizumi, T. Fukaya, M. Kubo, N. Yamashita, and K. Sato Regulatory dendritic cells protect against cutaneous chronic graft-versus-host disease mediated through CD4+CD25+Foxp3+ regulatory T cells Blood, November 15, 2007; 110(10): 3793 - 3803. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. E. Clark, S. R. Hingorani, R. Mick, C. Combs, D. A. Tuveson, and R. H. Vonderheide Dynamics of the Immune Reaction to Pancreatic Cancer from Inception to Invasion Cancer Res., October 1, 2007; 67(19): 9518 - 9527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Hubert, N. Jacobs, J.-H. Caberg, J. Boniver, and P. Delvenne The cross-talk between dendritic and regulatory T cells: good or evil? J. Leukoc. Biol., October 1, 2007; 82(4): 781 - 794. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. R. Turnquist, G. Raimondi, A. F. Zahorchak, R. T. Fischer, Z. Wang, and A. W. Thomson Rapamycin-Conditioned Dendritic Cells Are Poor Stimulators of Allogeneic CD4+ T Cells, but Enrich for Antigen-Specific Foxp3+ T Regulatory Cells and Promote Organ Transplant Tolerance J. Immunol., June 1, 2007; 178(11): 7018 - 7031. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. C. Liu, L. Y. Wong, T. Jang, A. H. Shah, I. Park, X. Yang, Q. Zhang, S. Lonning, B. A. Teicher, and C. Lee Tumor Evasion of the Immune System by Converting CD4+CD25- T Cells into CD4+CD25+ T Regulatory Cells: Role of Tumor-Derived TGF-beta J. Immunol., March 1, 2007; 178(5): 2883 - 2892. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Sharma, L. Zheng, U. S. Deshmukh, W. N. Jarjour, S.-s. J. Sung, S. M. Fu, and S.-T. Ju Cutting Edge: A Regulatory T Cell-Dependent Novel Function of CD25 (IL-2R{alpha}) Controlling Memory CD8+ T Cell Homeostasis J. Immunol., February 1, 2007; 178(3): 1251 - 1255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Hubeau, I. Apostolou, and L. Kobzik Targeting of CD25 and Glucocorticoid-Induced TNF Receptor Family-Related Gene-Expressing T Cells Differentially Modulates Asthma Risk in Offspring of Asthmatic and Normal Mother Mice J. Immunol., February 1, 2007; 178(3): 1477 - 1487. [Abstract] [Full Text] [PDF]
|
|