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International Immunology Advance Access originally published online on May 23, 2006
International Immunology 2006 18(7):991-1000; doi:10.1093/intimm/dxl044
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© The Japanese Society for Immunology. 2006. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

review-article

Emerging possibilities in the development and function of regulatory T cells

Kajsa Wing1, Zoltán Fehérvári1 and Shimon Sakaguchi1,2

1 Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Shogoin 53, Kawahara-cho, Sakyoku, Kyoto 606-8507, Japan
2 Core Research for Evolutional Science and Technology (CREST) Program, Japan Science and Technology Agency, Kawaguchi 332-0012, Japan

Correspondence to: K. Wing; E-mail: kajsa{at}frontier.kyoto-u.ac.jp

CD25+CD4+ Regulatory T cells (Treg) represent a unique population of lymphocytes capable of powerfully suppressing immune responses. A large body of experimental data have now confirmed the essential role played by these cells in a host of clinically relevant areas such as self-tolerance, transplantation, allergy and tumor/microbial immunity. Despite this mass of knowledge, significant gaps in our understanding of fundamental Treg biology remain, particularly regarding their development and mechanisms of suppression. In this review we attempt to highlight the current controversies and directions in which this exciting field is moving.

Keywords: adaptive regulatory T cell, CTLA-4, Foxp3, natural regulatory T cells, tolerance


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