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International Immunology Advance Access originally published online on April 12, 2006
International Immunology 2006 18(6):827-835; doi:10.1093/intimm/dxl019
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© The Japanese Society for Immunology. 2006. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

IL-4 influences the differentiation and the susceptibility to activation-induced cell death of human naive CD8+ T cells

Catherine Riou1, Alain R Dumont1, Bader Yassine-Diab1, Elias K Haddad1,2, and Rafick-Pierre Sekaly1,2,3,

1 Laboratoire d'Immunologie, Centre de recherche du CHUM, Pavillon Édouard-Asselin, Hôpital Saint-Luc, 264 René-Lévesque Boulevard E, Montréal, Québec H2X 1P1, Canada
2 Department of Microbiology and Immunology, McGill University, Montréal, Québec H3A 2B4, Canada
3 Département de Microbiologie et Immunologie, Université de Montréal, Montréal, Québec H3C 3J7, Canada

Correspondence to: R.-P. Sekaly; E-mail: rafick-pierre.sekaly{at}umontreal.ca

It is now well established that the cytokine environment influences the activation, differentiation, proliferation and death of T lymphocytes during the primary response to antigen. Using an in vitro model, we investigated the influence of IL-4, added at the onset of TCR stimulation, on phenotypic and functional markers of naive CD8+ T cell activation including the up-regulation of activation markers, proliferation as well as the susceptibility to activation-induced cell death (AICD). We report that IL-4, unlike IL-2 added at the onset of repeated TCR stimulation of naive CD8+ T cells prevents AICD, in part due to its ability to maintain the level of the survival-related protein Bcl-2. Moreover, TCR-triggered activation of naive CD8+ T cells in the presence of IL-4 leads to the development of a CD8+ T cell subset that proliferates normally, but which fails to exhibit characteristic activation parameters such as the up-regulation of CD25 and Granzyme B. Taken together, these results demonstrate that exposure to IL-4 during primary activation influences CD8+ T cell differentiation by inducing the development of a sub-population of AICD-resistant, proliferation-competent cells that do not show some of the typical features of CD8+ T cell activation.

Keywords: apoptosis, CTL, cytokine, T cell activation, T cell differentiation

Transmitting editor: R. M. Steinman


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