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International Immunology Advance Access originally published online on March 28, 2006
International Immunology 2006 18(5):671-677; doi:10.1093/intimm/dxl004
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© The Japanese Society for Immunology. 2006. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

c-Fos suppresses systemic inflammatory response to endotoxin

Neelanjan Ray1,2,, Masayoshi Kuwahara3, Yasunari Takada1, Kenta Maruyama1, Tomohiro Kawaguchi3, Hirokazu Tsubone3, Hiromichi Ishikawa1 and Koichi Matsuo1

1 Department of Microbiology and Immunology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, 160-8582 Tokyo, Japan
2 Medical Scholars Program, Vanderbilt University School of Medicine, Nashville, TN 37232-8300, USA
3 Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, 113-8657 Tokyo, Japan

Correspondence to: K. Matsuo; E-mail: matsuo{at}sc.itc.keio.ac.jp

We explored the role of the transcription factor c-Fos in lipopolysaccharide (LPS)-induced cytokine response using mice lacking c-Fos (Fos–/– mice). Compared with wild-type controls, Fos–/– macrophages and mice showed significantly enhanced production of tumour necrosis factor (TNF)-{alpha}, interleukin (IL)-6 and IL-12 p40, but reduced production of the anti-inflammatory cytokine IL-10. Bandshift analysis revealed that LPS-induced NF-{kappa}B binding activity to a functional site in the TNF-{alpha} promoter was significantly higher in Fos–/– than in wild-type macrophages. Using telemetry, we monitored body temperature and heart rate after LPS injection and found that Fos–/– mice undergo more severe hypothermia and bradycardia than wild-type mice. Such shock responses in Fos–/– mice were significantly reversed by neutralizing TNF-{alpha}. These data reveal a novel in vivo role for c-Fos as an anti-inflammatory transcription factor acting through suppression of NF-{kappa}B activity.

Keywords: AP-1, body temperature, cytokines, knockout mice, NF-{kappa}B, telemetry, TNF-{alpha}

Transmitting editor: R. A. Flavell


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