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International Immunology Advance Access originally published online on March 30, 2006
International Immunology 2006 18(5):645-651; doi:10.1093/intimm/dxh397
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© The Japanese Society for Immunology. 2006. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Requirement of high-affinity IL-2–IL-2R interaction for T cell anergy induction

Robert J Hayashi1 and Osami Kanagawa1,2,

1 Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
2 Riken Research Center for Allergy and Immunology, RIKEN Yokohama Institute, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan

Correspondence to: O. Kanagawa; E-mail: kanagawa{at}rcai.riken.jp

Incomplete T cell antigen receptor-mediated signaling induces an unresponsive state known as anergy. Previously, we had shown that anergy can be induced in antigen-primed but not naive T cells. In this report, we found that in vitro primed T cells from IL-2R{alpha}-deficient mice were resistant to anergy induction in contrast to comparably treated wild-type T cells. This resistance persisted even after proliferation of IL-2R{alpha} chain-deficient CD4 T cells with high-dose IL-2–IL-2Rß{gamma} chains interaction. Thus, antigen activation, and/or progression through cell cycle are not sufficient to induce anergy susceptibility in T cells. The high-affinity IL-2–IL-2R interaction appears to play a critical role in this process.

Keywords: CD4, IL-2, IL-2R, tolerance

Transmitting editor: K. M. Murphy


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