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International Immunology Advance Access originally published online on January 23, 2006
International Immunology 2006 18(3):465-471; doi:10.1093/intimm/dxh387
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© The Japanese Society for Immunology. 2006. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Trypanosoma cruzi modulates the profile of memory CD8+ T cells in chronic Chagas' disease patients

María Cecilia Albareda1, Susana Adriana Laucella1, María Gabriela Alvarez2, Alejandro Hector Armenti2, Graciela Bertochi2, Rick L. Tarleton3 and Miriam Postan1

1 Instituto Nacional de Parasitología Dr. Mario Fatala Chabén/ANLIS/Malbrán, Av. Paseo Colón 568 (1063), Buenos Aires, Argentina
2 Hospital Interzonal General de Agudos Eva Perón, San Martín, Provincia de Buenos Aires, Argentina
3 Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA, USA

Correspondence to: M. Postan; E-mail: mpostan{at}mail.retina.ar

We present a cross-sectional analysis of the maturation and migratory properties of the memory CD8+ T cell compartment, in relation to the severity of heart disease in individuals with chronic Trypanosoma cruzi infection removed from endemic areas for longer than 20 years. Subjects with none or mild heart involvement were more likely to mount T. cruzi-specific memory IFN-{gamma} responses than subjects with more advanced cardiac disease, and the T. cruzi-specific CD8+ T cell population was enriched in early-differentiated (CD27+CD28+) cells in responding individuals. In contrast, the frequency of CD27+CD28+CD8+ T cells in the total memory CD8+ T cell population decreases, as disease becomes more severe, while the proportion of fully differentiated memory (CD27–CD28–) CD8+ T cells increases. The analysis of CCR7 expression revealed a significant increase in total effector/memory CD8+ T cells (CD45RA–CCR7–) in subjects with mild heart disease as compared with uninfected controls. Altogether, these results are consistent with the hypothesis of a gradual clonal exhaustion in the CD8+ T cell population, perhaps as a result of continuous antigenic stimulation by persistent parasites.

Keywords: CD8+ T cell maturation profile, CD27, CD28, CD45RA, parasitic infection

Transmitting editor: S. H. E. Kaufmann


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