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International Immunology Advance Access originally published online on January 17, 2006
International Immunology 2006 18(2):249-257; doi:10.1093/intimm/dxh360
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© The Japanese Society for Immunology. 2006. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Neonate-primed CD8+ memory cells rival adult-primed memory cells in antigen-driven expansion and anti-viral protection

Shaza A. Fadel1,5, Lindsay G. Cowell2, Shui Cao1,3, Daniel A. Ozaki1, Thomas B. Kepler2, Douglas A. Steeber4 and Marcella Sarzotti1

1 Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
2 Department of Biostatistics and Bioinformatics, Center for Bioinformatics and Computational Biology, Duke University Medical Center, Durham, NC 27708, USA
3 Immunology Department, Tianjin Cancer Hospital and Institute, Tianjin Medical University, Huanhu Xilu, Tiyuanbei, Hexi District, Tianjin 300060, China
4 Department of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA
5 Present address: Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, 149 East 13th Street, Charlestown, MA 02129, USA

Correspondence to: M. Sarzotti; E-mail: msarzott{at}duke.edu

Immunizations early in life, when the host is most susceptible to infection, allow protective immunological memory to develop. Decreasing the dose of Cas-Br-E murine leukemia virus when priming neonatal mice results in adult-like, Type 1 protective responses, but the resulting memory cell populations are smaller than after adult priming. After secondary challenge, virus-specific CD8+ memory cell populations expand twice as much in neonate-primed mice as in adult-primed mice. We found that when equivalent numbers of virus-specific cells were transferred into virus-susceptible mice, protection from disease was similar whether donor, immune mice were primed as neonates or adults, and IL-4 did not alter in vivo virus-specific CD8+ memory cell effector function. Hence, neonate-primed CD8+ cells develop into memory cells that rival adult-primed cells in proliferation and effector function.

Keywords: cytokines, memory, rodent, T lymphocytes, viral

Transmitting editor: T. Tedder


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[Abstract] [Full Text] [PDF]


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