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International Immunology Advance Access originally published online on September 20, 2006
International Immunology 2006 18(11):1607-1613; doi:10.1093/intimm/dxl093
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© The Japanese Society for Immunology. 2006. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Competition controls the rate of transition between the peripheral pools of CD4+CD25– and CD4+CD25+ T cells

Afonso R. M. Almeida1, Bruno Zaragoza and Antonio A. Freitas

Lymphocyte Population Biology Unit, URA CNRS 1961, Institut Pasteur, 28 Rue du Dr. Roux, 75015 Paris, France
1 Present address: Institute for Research in Biomedicine, Bellinzona, Switzerland

Correspondence to: A. A. Freitas; E-mail: afreitas{at}pasteur.fr and A. R. M. Almeida; E-mail: afonso.almeida{at}irb.unisi.ch

Recent reports have hinted that it is possible to regenerate CD4+CD25+ regulatory T cells (Treg) from CD4+CD25– cells, a phenomenon termed conversion. We evaluated the relative contribution of this process to the Treg pool by transferring purified populations of CD4+ T cells into T cell-deficient mice. We report that conversion of CD25– cells into the CD4+CD25+Treg pool is minor if other bona fide CD25+ Tregs are present. Moreover, in the same hosts, the loss of CD25 expression by a population of Tregs also decreases in the presence of co-injected CD4+CD25– cells. Thus, the rate of exchange between CD25– and CD25+ T-cell populations is determined by the presence or absence of T-cell competitors. Our results attest for the role of competition in the contribution of different T-cell subsets for the regeneration of the peripheral CD4+ T-cell pool during lymphopenia.

Keywords: IL-2, lymphopenia-driven proliferation, regulatory T cells, T-cell homeostasis

Transmitting editor: T. Watanabe


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