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International Immunology Advance Access originally published online on September 20, 2006
International Immunology 2006 18(11):1585-1590; doi:10.1093/intimm/dxl091
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© The Japanese Society for Immunology. 2006. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

The 8.1 ancestral MHC haplotype is associated with delayed onset of colonization in cystic fibrosis

Judit Laki1,2, István Laki3, Krisztina Németh4, Rita Újhelyi5, Olga Bede6, Emoke Endreffy6, Katalin Bolbás3, Kálmán Gyurkovits3, Eszter Csiszér7, Eniko Sólyom8, Gergely Dobra3, Adrienn Halász9, Éva Pozsonyi10, Katalin Rajczy10, Zoltán Prohászka1,2, György Fekete4 and George Füst1,11

1 Third Department of Medicine, Semmelweis University, 1125 Budapest, Kútvölgyi út 4, Hungary
2 Research Group of Atherosclerosis and Metabolism, Hungarian Academy of Sciences, 1125 Budapest, Kútvölgyi út 4, Hungary
3 Department of Pediatrics, Hospital for Chest Diseases of the Reformed Church of Hungary, 7257 Mosdós, Petofi u. 4, Hungary
4 Second Department of Pediatrics, Semmelweis University, 1094 Budapest, Tuzoltó u. 7-9, Hungary
5 Department of Pediatric Pulmonology, Heim Pál Children's Hospital, 1089 Budapest, Ülloi út 86, Hungary
6 Department of Pediatrics, University of Szeged, Albert Szent-Györgyi Medical School, 6725 Szeged, Korányi Fasor 14-15, Hungary
7 Third Department of Pulmonology, National Korányi Institute for TB and Pulmonology, 1529 Budapest, Piheno út 1, Hungary
8 Department of Pediatric Gastroenterology, Borsod-A-Z County and University Teaching Hospital, Pediatric Health Centre, 3526 Miskolc, Szentpéteri kapu 72-76, Hungary
9 Department of Pediatric Pulmonology (III), Svabhegy Children's Hospital, 1121 Budapest, Mártonhegyi út 6, Hungary
10 National Medical Center, Institute of Haematology and Immunology, 1113 Budapest, Daróci u. 24, Hungary
11 Szentágothai János Knowledge Center, Semmelweis University, Budapest, Ülloi út 26, Hungary

Correspondence to: J. Laki; E-mail: lakij{at}kut.sote.hu

Major cause of death in patients with cystic fibrosis (CF) is colonization with Staphylococcus aureus and Pseudomonas aeruginosa. The wide phenotypic variation in CF patients suggests that genes other than the cystic fibrosis transmembrane conductance regulator (CFTR) gene modify the disease. The 8.1 ancestral haplotype (8.1AH) in main histocompatibility complex is associated with alterations of the immune response. To study the influence of carriage of 8.1AH on frequency and onset of colonization in CF patients, DNA samples of 72 CF patients (39 homozygous and 33 heterozygous for {Delta}F508) were genotyped for member alleles of the 8.1AH: HLA-DQB1*0201, HLA-DRB1*0301, receptor for advanced glycation end products (AGER) –429C, HSP70-2 –1267G (HSP70-2G) and tumor necrosis factor-{alpha} (TNF-{alpha}) –308A (TNF2). Colonization was verified by regular clinical and bacteriological screening. Frequency of colonization was significantly (P = 0.012) lower in the 8.1AH carriers; age, gender and {Delta}F508 genotype-adjusted odds ratio to be colonized of the carriers versus non-carriers was 0.112 (0.024–0.520). According to survival analysis, patients with 8.1AH had significantly (P < 0.0001) longer colonization-free period compared with non-carriers. Our novel observations demonstrate that the 8.1AH is associated with delayed onset of colonization in CF, presumably by influencing defense mechanisms against infections.

Keywords: cystic fibrosis, HLA, infection, MHC, TNF-{alpha}

Transmitting editor: A. Falus


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