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International Immunology Advance Access originally published online on January 10, 2005
International Immunology 2005 17(2):193-205; doi:10.1093/intimm/dxh200
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© 2005 The Japanese Society for Immunology

The combined effect of IL-4 and IL-10 suppresses the generation of, but does not change the polarity of, type-1 T cells in Histoplasma infection

Jung-Kuei Peng1, Jr-Shiuan Lin1, John T. Kung2, Fred D. Finkelman3,4 and Betty A. Wu-Hsieh1

1 Graduate Institute of Immunology, College of Medicine, National Taiwan University, No. 1 Jen-Ai Road, Section 1, Taipei 100, Taiwan, Republic of China
2 Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan, Republic of China
3 Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
4 Cincinnati Veterans Administration Medical Center, Cincinnati, OH 45220, USA

Correspondence to: B. A. Wu-Hsieh; E-mail: wuhsiehb{at}ha.mc.ntu.edu.tw

Dominant type-1 cytokine production is induced in a murine model of systemic histoplasmosis. We used this model to investigate whether the presence of antagonistic cytokines during T cell priming changes the polarity of T cells in response to Histoplasma infection. Before infection with Histoplasma capsulatum, mice were injected twice with goat anti-mouse IgD antiserum (G{alpha}M{delta}), which induced expression of dominant type-2 cytokines. At days 7 and 14 after infection, the G{alpha}M{delta}-treated mice had suppressed IFN-{gamma} response and a significantly greater fungal burden in their spleens and lungs. The number of IFN-{gamma}-producing cells as well as the level of IFN-{gamma} produced per cell was greatly reduced. Not only CD4+ T cells but also CD8+ T cells were affected. The number of Histoplasma-induced IFN-{gamma}-producing cells was partially restored in G{alpha}M{delta}-treated IL-4–/– and IL-10–/– mice and completely restored in IL-4–/–IL-10–/– mice. Thus, the combined effect of IL-4 and IL-10 suppressed the generation of IFN-{gamma}-producing cells. A longitudinal study demonstrated that as IL-4 and IL-10 decreased, the number of Histoplasma-induced IFN-{gamma}-producing cells rapidly increased, and fungal clearance improved, demonstrating that the presence of IL-4 and IL-10 did not permanently change the polarity of T cells.

Keywords: histoplasmosis, IFN-{gamma}-producing cells, T cell polarity, type-1 and type-2 cytokines

Transmitting editor: A. Cooke


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