International Immunology Advance Access originally published online on August 9, 2004
International Immunology 2004 16(9):1343-1353; doi:10.1093/intimm/dxh137
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© 2004 The Japanese Society for Immunology
FEATURED ARTICLE OF THE MONTH |
Differential B cell expression of mouse Fc receptor homologs
1 Division of Developmental and Clinical Immunology, 2 Division of Hematology/Oncology, 3 Department of Medicine, 4 Department of Pediatrics, 5 Department of Pathology and 6 Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294-3300, USA
7 Howard Hughes Medical Institute, Birmingham, AL 35294-3300, USA
8 Laboratory of Immunopathogenesis and Bioinformatics, Science Applications International Corporation-Frederick, Building 550, Room 204 FCRDC PO Box B, Boyles Street, Frederick, MD 21702–1201, USA
9 Present address: Department of Pathology, Stanford University, 269 Campus Drive, Room CCSR 3250, Stanford, CA 94305–5176, USA
Correspondence to: M. D. Cooper; E-mail: max.cooper{at}ccc.uab.edu
Five Fc receptor homologs (FcRH1–5) possessing inhibitory and/or activating signaling motifs are differentially expressed during B cell differentiation in humans. In this analysis we describe their three mouse orthologs, moFcRH1, moFcRH2 and moFcRH3. The moFcRH genes are located in a chromosome 3 region that is syntenic with the FcRH locus on human chromosome 1. They encode proteins with 2–5 Ig-like domains that share 20–61% extracellular identity with their human counterparts. One moFcRH1 isoform lacks a transmembrane domain as do both moFcRH2 isoforms. The other moFcRH1 isoform and two moFcRH3 isoforms have transmembrane domains and cytoplasmic ITIM and ITAM-like consensus sequences implying their inhibitory or activating signaling potential. Whereas the moFcRH1 and moFcRH3 orthologs are preferentially expressed at different stages in B cell differentiation, the structurally novel moFcRH2 gene is expressed in non-lymphoid tissues. The highly restricted pattern of moFcRH3 expression suggests this member of the phylogenetically conserved FcRH family may have an important immunoregulatory role in marginal zone B cells.
Keywords: B cell differentiation, Fc receptors, immunoglobulin superfamily, immunoreceptor tyrosine-based motifs, phylogeny
NCBI accession nos: moFcRH1L, AY506554; moFcRH1S, AY506555; moFcRH2sc, AY506556; moFcRH2Lg, AY506557; moFcRH3, AY506558.
Transmitting editor: T. Watanabe
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