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International Immunology Advance Access originally published online on July 19, 2004
International Immunology 2004 16(9):1237-1240; doi:10.1093/intimm/dxh125
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© 2004 The Japanese Society for Immunology

CD4+ T cells are important for clearance of DA strain of TMEV from the central nervous system of SJL/J mice

Xiaoqi Lin1, Xiaoxing Ma1, Moses Rodriguez2 and Raymond P. Roos1

1 Department of Neurology, University of Chicago, Chicago, IL 60637, USA
2 Departments of Neurology and Immunology, Mayo Clinic, Rochester, MN 55905, USA

Correspondence to: R. P. Roos; E-mail: rroos{at}neurology.bsd.uchicago.edu

DA and other TO subgroup strains of Theiler's murine encephalomyelitis virus synthesize a protein called L* which interferes with DA virus clearance from the central nervous system of susceptible SJL mice, thereby fostering virus persistence and a late demyelinating disease. By using CD4 (–/–) and CD8 (–/–) mice as well as adoptive transfer studies we demonstrate that susceptible mouse strains are capable of clearing DA virus through a CD4+ T cell-dependent activity that is inhibited by L*.

Keywords: anti-virus immunity, immune-mediated demyelination

The first two authors contributed equally to this work.

Transmitting editor: L. Steinman


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