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International Immunology Advance Access originally published online on June 7, 2004
International Immunology 2004 16(7):1019-1025; doi:10.1093/intimm/dxh103
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International Immunology, Vol. 16, No. 7, pp. 1019-1025, July 2004
© 2004 Japanese Society for Immunology

Involvement of FcR{gamma} in signal transduction of osteoclast-associated receptor (OSCAR)

Satoru Ishikawa1, Noriko Arase1,3, Tadashi Suenaga1, Yoshitomo Saita4, Masaki Noda4, Takayuki Kuriyama2, Hisashi Arase1,5,6 and Takashi Saito1,3

1 Department of Molecular Genetics and 2 Department of Respirology, Chiba University Graduate School of Medicine, Chiba, Japan 3 Laboratory for Cell Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan 4 Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan 5 Research Institute for Microbial Diseases, Osaka University, Yamadaoka 3-1, Suita, Osaka 565-0871, Japan 6 PRESTO, Japan Science and Technology Agency, Saitama, Japan

Correspondence to: H. Arase; E-mail: arase{at}biken.osaka-u.ac.jp
Transmitting editor: H. Karasuyama

Osteoclasts regulate homeostasis of bone development. A defect in osteoclast development results in osteopetrosis. Recently, the involvement of several molecules in osteoclast development has been found. Osteoclast-associated receptor (OSCAR) is one of such molecules critical for osteoclast differentiation. However, it remains unclear how OSCAR transduces signals for osteoclast differentiation. Here, we found that the FcR{gamma} chain, a signal transducing adaptor molecule for Fc receptors, is associated with OSCAR and is involved in the cell surface expression of OSCAR. Furthermore, FcR{gamma} is required for signal transduction by OSCAR. These findings suggest that the FcR{gamma}-mediated signal transduction by OSCAR is involved in osteoclast differentiation.

Keywords: CD3{zeta}, Fc receptor, Ig-like receptor, ITAM, osteoclast


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