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International Immunology, Vol. 16, No. 3, pp. 467-475, March 2004
© 2004 Japanese Society for Immunology

BAFF production by antigen-presenting cells provides T cell co-stimulation

Bertrand Huard1, Lionel Arlettaz2, Christine Ambrose1, Vincent Kindler4, Davide Mauri5, Eddy Roosnek2, Jürg Tschopp6, Pascal Schneider6 and Lars E. French1

1 Department of Dermatology, University Medical Center, 1 rue Michel-Servet, 7211 Geneva 4, Switzerland 2 Division of Immunology and Allergology, University Hospital, Geneva 7211, Switzerland 3 Department of Gene Discovery, Biogen, Cambridge, MA 02148, USA 4 Division of Hematology, University Hospital, Geneva 1211, Switzerland 5 Apotech Corp., Epalinges 1066, Switzerland 6 Institute of Biochemistry, Lausanne University, Epalinges 1066, Switzerland

Correspondence to: B. Huard; E-mail: Bertrand.huard{at}medecine.unige.ch
Transmitting editor: H. Robson-McDonald

The B cell-activating factor from the tumor necrosis factor family (BAFF) is an important regulator of B cell immunity. Recently, we demonstrated that recombinant BAFF also provides a co-stimulatory signal to T cells. Here, we studied expression of BAFF in peripheral blood leukocytes and correlated this expression with BAFF T cell co-stimulatory function. BAFF is produced by antigen-presenting cells (APC). Blood dendritic cells (DC) as well as DC differentiated in vitro from monocytes or CD34+ stem cells express BAFF mRNA. Exposure to bacterial products further up-regulates BAFF production in these cells. A low level of BAFF transcription, up-regulated upon TCR stimulation, was also detected in T cells. Functionally, blockade of endogenous BAFF produced by APC and, to a lesser extent, by T cells inhibits T cell activation. Altogether, this indicates that BAFF may regulate T cell immunity during APC–T cell interactions and as an autocrine factor once T cells have detached from the APC.

Keywords: antigen-presenting cell, co-stimulation, T cell, tumor necrosis factor


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