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International Immunology, Vol. 16, No. 2, pp. 315-326, February 2004
© 2004 Japanese Society for Immunology

Immunologic immaturity, but high IL-4 productivity, of murine neonatal thymic CD4 single-positive T cells in the last stage of maturation

Madoka Koyanagi1, Ken’ichi Imanishi1, Yutaka Arimura1, Hidehito Kato1, Junji Yagi1 and Takehiko Uchiyama1

1 Department of Microbiology and Immunology, School of Medicine, Tokyo Women’s Medical University,8-1 Kawada-Cho, Shinjuku-Ku, Tokyo 162-8666, Japan

Correspondence to: T. Uchiyama; E-mail: tuchi{at}research.twmu.ac.jp
Transmitting editor: S. Koyasu

To determine the levels of maturation and differentiation of murine CD4 single-positive (SP) T cells, we compared the secondary responses of staphylococcal enterotoxin A (SEA)-induced neonatal thymic, adult thymic and adult splenic CD4 SP T cell blasts prepared from whole or heat-stable antigenlow CD4 SP T cells. Proliferative responses upon re-stimulation with SEA were strong in adult splenic CD4 SP T cell blasts, but quite weak in neonatal thymic and adult thymic CD4 SP T cell blasts. SEA-induced IL-2 production was weaker in neonatal thymic blasts than in the adult splenic CD4 SP T cell blasts. In contrast, SEA-induced IL-4 production was high in neonatal thymic CD4 SP T cell blasts, and low in adult splenic and thymic CD4 SP T cell blasts. Expression of GATA-3, that directs production of IL-4 in T cells, examined at protein and mRNA levels, was higher in neonatal thymic cells than in adult thymic and splenic cells. These results suggest that neonatal and adult thymic CD4 SP T cells in the final stage of maturation are relatively immature compared with adult splenic CD4 SP T cells. The cytokine production profile of neonatal thymic CD4 SP T cells suggests that they are inclined towards a Th2 response.

Keywords: anergy, cytokine, neonate, Th1/Th2 cell, thymus


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[Abstract] [Full Text] [PDF]


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