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International Immunology, Vol. 16, No. 2, pp. 231-240, February 2004
© 2004 Japanese Society for Immunology

Coronin-1 expression in T lymphocytes: insights into protein function during T cell development and activation

Béatrice Nal1,2, Patrick Carroll3, Elodie Mohr1, Christophe Verthuy1, Maria-Isabel Da Silva1, Odile Gayet3, Xiao-Jun Guo1,4, Hai-Tao He1, Andrés Alcover2 and Pierre Ferrier1

1 Centre d‘Immunologie de Marseille–Luminy, INSERM–CNRS–Université de la Méditerranée, Case 906, 13288 Marseille Cedex 9, France 2 Unité de Biologie des Interactions Cellulaires, CNRS URA 2582, Institut Pasteur, Paris 75724, France 3 Institut de Biologie du Développement de Marseille (IBDM), INSERM U382, Marseille 13288, France 4 Institut Méditerranéen de Recherche en Nutrition, UMR-INRA, Marseille 13397, France

Correspondence to: P. Ferrier; E-mail: ferrier{at}ciml.univ-mrs.fr
Transmitting editor: J. Borst

Coronin has been described as an actin-binding protein of Dictyostelium discoideum, and it has been demonstrated to play a role in cell migration, cytokinesis and phagocytosis. Coronin-related proteins are found in many eukaryotic species, including Coronin-1 in mammals whose expression is enriched in the hematopoietic tissues. Here, we characterize Coronin-1 gene and protein expression in mouse embryonic and adult T lymphocytes. Coronin-1 is expressed throughout T cell ontogeny and in peripheral {alpha}ß T cells. Expression varies along thymic cell development, with maximum levels observed in embryonic early thymocytes and, in the adults, the selected TCR{alpha}ß+ single-positive thymocytes. Subcellular localization analysis indicates that Coronin-1 is in equilibrium between the cytosol and the cell cortex, where it accumulates in F-actin-rich membrane protrusions induced by polarized activation of TCR–CD3-stimulated T cells. These data are consistent with a role of Coronin-1 in T cell differentiation/activation events involving membrane dynamisms and the cortical actin cytoskeleton.

Keywords: actin cytoskeleton, Coronin, T lymphocyte


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