Skip Navigation


International Immunology Advance Access originally published online on September 20, 2004
International Immunology 2004 16(11):1595-1604; doi:10.1093/intimm/dxh160
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
16/11/1595    most recent
dxh160v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (10)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Köller, M.
Right arrow Articles by Scheinecker, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Köller, M.
Right arrow Articles by Scheinecker, C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


© 2004 The Japanese Society for Immunology

Phenotypic and functional deficiencies of monocyte-derived dendritic cells in systemic lupus erythematosus (SLE) patients

Marcus Köller, Bettina Zwölfer, Günter Steiner, Josef S. Smolen and Clemens Scheinecker

Department of Rheumatology, Internal Medicine III, Medical University of Vienna, General Hospital of Vienna, Währingergürtel 18-20, A-1090 Vienna, Austria

Correspondence to: C. Scheinecker; E-mail: clemens.scheinecker{at}meduniwien.ac.at

Systemic lupus erythematosus (SLE) represents an autoimmune disease for which alterations of T cells, B cells as well as various antigen-presenting cell (APC) populations have been described. In order to better define APC-associated deficiencies, we analyzed morphologic, phenotypic and functional characteristics of in vitro-generated monocyte-derived dendritic cells (MoDC) from SLE patients as compared with healthy controls. Analysis of MoDC at different stages of maturation revealed substantial phenotypic and functional defects of MoDC from SLE patients as compared with healthy controls. In particular, we observed a significantly reduced up-regulation of MHC class II molecules on MoDC upon activation which correlated with disease activity scores and functional deficiencies in mixed lymphocyte reaction experiments. Our data imply a crucial role of APC in the immunological imbalance in SLE for foreign and self-antigen reactivity.

Keywords: SLE, dendritic cells, monocytes, toll-like receptors

Transmitting editor: M. Feldmann


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 LupusHome page
O. Jin, S. Kavikondala, L. Sun, R. Fu, M.-Y. Mok, A. Chan, J. Yeung, and C.-S. Lau
Systemic lupus erythematosus patients have increased number of circulating plasmacytoid dendritic cells, but decreased myeloid dendritic cells with deficient CD83 expression
Lupus, July 1, 2008; 17(7): 654 - 662.
[Abstract] [PDF]

Home page
 J. Immunol.Home page
E. A. Laborde, S. Vanzulli, M. Beigier-Bompadre, M. A. Isturiz, R. A. Ruggiero, M. G. Fourcade, A. C. Catalan Pellet, S. Sozzani, and M. Vulcano
Immune Complexes Inhibit Differentiation, Maturation, and Function of Human Monocyte-Derived Dendritic Cells
J. Immunol., July 1, 2007; 179(1): 673 - 681.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Ding, H. Mehta, W. J. McCune, and M. J. Kaplan
Aberrant Phenotype and Function of Myeloid Dendritic Cells in Systemic Lupus Erythematosus
J. Immunol., November 1, 2006; 177(9): 5878 - 5889.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
P. Decker, I. Kotter, R. Klein, B. Berner, and H.-G. Rammensee
Monocyte-derived dendritic cells over-express CD86 in patients with systemic lupus erythematosus
Rheumatology, September 1, 2006; 45(9): 1087 - 1095.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.