Skip Navigation


International Immunology Advance Access originally published online on September 6, 2004
International Immunology 2004 16(11):1549-1559; doi:10.1093/intimm/dxh156
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
16/11/1549    most recent
dxh156v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (10)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Zhong, W.
Right arrow Articles by Reinherz, E. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhong, W.
Right arrow Articles by Reinherz, E. L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


© 2004 The Japanese Society for Immunology

In vivo selection of a TCR Vß repertoire directed against an immunodominant influenza virus CTL epitope

Weimin Zhong and Ellis L. Reinherz

Laboratory of Immunobiology and Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA, USA

Correspondence to: W. Zhong; E-mail: weimin_zhong{at}dfci.harvard.edu

Correspondence to: E. Reinherz; E-mail: ellis_reinherz{at}dfci.harvard.edu

Little is known about the mechanisms governing TCR repertoire selection in response to foreign antigens. Here, we evaluate the molecular features of the murine C57BL/6 (B6) TCR Vß repertoire directed at the NP366–374 immunodominant epitope of the influenza virus nucleoprotein. Common or ‘public’ ß chains are shared among individuals following either primary or secondary infection. Importantly, repertoire diversity decreases substantially after a second viral exposure due to enrichment of TCRs sharing Vß CDR3 loops of identical length and highly related amino acid sequences. TCRs from these secondary T cell populations possess greater overall avidity for the NP366–374/Db complex compared to those from the primary repertoire. Thus, expansion of CD8+ T cells expressing a favored germline Vß gene segment in the primary response and further selection for CDR3ß loops during the secondary response, contribute to optimization of immune recognition against certain viral epitopes.

Keywords: influenza virus, repertoire, T cell receptor, vaccination

Transmitting editor: S. Koyasu


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
P. Wettstein, M. Strausbauch, T. Therneau, and N. Borson
The application of real-time PCR to the analysis of T cell repertoires
Nucleic Acids Res., December 1, 2008; 36(21): e140 - e140.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Kedzierska, P. G. Thomas, V. Venturi, M. P. Davenport, P. C. Doherty, S. J. Turner, and N. L. La Gruta
Terminal Deoxynucleotidyltransferase Is Required for the Establishment of Private Virus-Specific CD8+ TCR Repertoires and Facilitates Optimal CTL Responses
J. Immunol., August 15, 2008; 181(4): 2556 - 2562.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
V. Venturi, H. Y. Chin, D. A. Price, D. C. Douek, and M. P. Davenport
The Role of Production Frequency in the Sharing of Simian Immunodeficiency Virus-Specific CD8+ TCRs between Macaques
J. Immunol., August 15, 2008; 181(4): 2597 - 2609.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Kedzierska, V. Venturi, S. A. Valkenburg, M. P. Davenport, S. J. Turner, and P. C. Doherty
Homogenization of TCR Repertoires within Secondary CD62Lhigh and CD62Llow Virus-Specific CD8+ T Cell Populations
J. Immunol., June 15, 2008; 180(12): 7938 - 7947.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
E. J. Yager, M. Ahmed, K. Lanzer, T. D. Randall, D. L. Woodland, and M. A. Blackman
Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus
J. Exp. Med., March 17, 2008; 205(3): 711 - 723.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
P. J. Wettstein, M. Strausbauch, and N. Borson
Repertoires of T cell receptors expressed by graft-infiltrating T cells evolve during long-term recall responses to single minor histocompatibility antigens
Int. Immunol., April 1, 2007; 19(4): 523 - 534.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Kedzierska, E. B. Day, J. Pi, S. B. Heard, P. C. Doherty, S. J. Turner, and S. Perlman
Quantification of Repertoire Diversity of Influenza-Specific Epitopes with Predominant Public or Private TCR Usage
J. Immunol., November 15, 2006; 177(10): 6705 - 6712.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.