Skip Navigation


International Immunology Advance Access originally published online on September 6, 2004
International Immunology 2004 16(10):1497-1505; doi:10.1093/intimm/dxh151
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
16/10/1497    most recent
dxh151v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (13)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Hoshino, A.
Right arrow Articles by Nishimura, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hoshino, A.
Right arrow Articles by Nishimura, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


© 2004 The Japanese Society for Immunology

STAT6-mediated signaling in Th2-dependent allergic asthma: critical role for the development of eosinophilia, airway hyper-responsiveness and mucus hypersecretion, distinct from its role in Th2 differentiation

Akihiko Hoshino1, Takemasa Tsuji2, Junko Matsuzaki2, Takafumi Jinushi2, Shigeru Ashino2, Takashi Teramura2, Kenji Chamoto2, Yoshitaka Tanaka1, Yumiko Asakura1, Takanobu Sakurai1, Yasuo Mita1, Akiko Takaoka1, Shiro Nakaike1, Tsuguhide Takeshima2, Hiroaki Ikeda2 and Takashi Nishimura2

1 Medicinal Research Laboratory, Taisho Pharmaceutical Co., Ltd, Saitama, Japan
2 Division of Immunoregulation, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan

Correspondence to: T. Nishimura; E-mail: tak24{at}igm.hokudai.ac.jp

When wild-type BALB/c mice were transferred with OVA-specific Th2 cells followed by OVA inhalation, a severe eosinophilia, mucus hypersecretion and airway hyper-responsiveness (AHR) was induced in parallel with a marked elevation of IL-4, IL-5 and IL-13 levels in bronchoalveolar lavage fluid (BALF). However, neither eosinophilia, AHR nor mucus hypersecretion was induced in Th2 cell-transferred STAT6–/– mice. The failure of eosinophilia was not due to the defect of Th2 cytokine production in BALF of STAT6–/– mice transferred with Th2 cells, but because of the defect of STAT6-dependent eotaxin production. Indeed, intranasal administration of eotaxin reconstituted pulmonary eosinophilia but not AHR and mucus hypersecretion in OVA-inhalated STAT6–/– mice. These results initially provided direct evidence that STAT6-dependent eotaxin production is essential for pulmonary eosinophilia. We also dissociated the role of STAT6 for eosinophilia from that for AHR and mucus hypersecretion. Thus, STAT6 also plays a critical role at late phase of Th2-dependent allergy induction.

Keywords: allergy, chemokines, eosinophils, lung, transcription factors

Transmitting editor: K. Sugamura


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Immunol.Home page
B. D. Medoff, E. Seung, S. Hong, S. Y. Thomas, B. P. Sandall, J. S. Duffield, D. A. Kuperman, D. J. Erle, and A. D. Luster
CD11b+ Myeloid Cells Are the Key Mediators of Th2 Cell Homing into the Airway in Allergic Inflammation
J. Immunol., January 1, 2009; 182(1): 623 - 635.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
S. Ashino, D. Wakita, Y. Zhang, K. Chamoto, H. Kitamura, and T. Nishimura
CpG-ODN inhibits airway inflammation at effector phase through down-regulation of antigen-specific Th2-cell migration into lung
Int. Immunol., February 1, 2008; 20(2): 259 - 266.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. T. Kasaian, D. D. Donaldson, L. Tchistiakova, K. Marquette, X.-Y. Tan, A. Ahmed, B. A. Jacobson, A. Widom, T. A. Cook, X. Xu, et al.
Efficacy of IL-13 Neutralization in a Sheep Model of Experimental Asthma
Am. J. Respir. Cell Mol. Biol., March 1, 2007; 36(3): 368 - 376.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.