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International Immunology Advance Access originally published online on September 6, 2004
International Immunology 2004 16(10):1355-1364; doi:10.1093/intimm/dxh132
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© 2004 The Japanese Society for Immunology

T cell expression of CIITA represses Th1 immunity

Weon Seo Park1, Youngmee Bae1, Doo Hyun Chung3, Yoon-La Choi3,4, Byoung Kwon Kim3, Young Chul Sung5, Eun Young Choi3,4, Seong Hoe Park3,4 and Kyeong Cheon Jung2

1 Department of Pathology, Kangwon University College of Medicine, Chunchon, Korea
2 Department of Pathology, Hallym University College of Medicine, Chunchon, Korea
3 Department of Pathology, College of Medicine and 4 Research Division for Human Life Science, Seoul National University, Seoul, Korea
5 Department of Life Science, Pohang University of Science and Technology, Pohang, Korea

Correspondence to: S. H. Park; E-mail: pshoe{at}plaza.snu.ac.kr

Correspondence to: K. C. Jung; E-mail: jungkc66{at}snu.ac.kr

Despite the fact that major histocompatibility complex class II transactivator (CIITA) has been known to be involved in Th1/Th2 balance in addition to its major role as a master regulator for the expression of MHC class II genes, the exact role of CIITA in Th1/Th2 balance is still controversial. To investigate whether the Th1/Th2 balance could be modulated by T cell specific expression of CIITA, we generated CIITA-transgenic mice, in which the CIITA expression is controlled by the distal promoter of p56lck, resulting in constitutive expression of CIITA predominantly in peripheral T cells. Naive CD4+ T cells from CIITA-transgenic mice exhibited a low level of IFN-{gamma} secretion as well as impaired Th1 polarization in vitro, while IL-4 secretion was enhanced under Th2 condition. In addition, the development of experimental autoimmune encephalomyelitis (EAE), a prototype of Th1-mediated disease, was repressed in CIITA-transgenic mice. Resistance to EAE was correlated with reduced production of IFN-{gamma} in response to MOG35–55, while the proliferation of MOG35–55-specific T cells was not affected in CIITA-transgenic mice. Together, these data demonstrate that overexpression of CIITA in T cells inhibits Th1 differentiation and function, suggesting that the expression of CIITA in T cells might play a role in the regulation of the Th1/Th2 balance during the T cell lineage commitment.

Keywords: experimental autoimmune encephalomyelitis, IFN-{gamma}, MHC class II, transgenic mouse

Transmitting editor: E. Simpson


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