International Immunology, Vol. 16, No. 1, pp. 149-161,
January 2004
© 2004 Japanese Society for Immunology
The exploitation of distinct recognition receptors in dendritic cells determines the full range of host immune relationships with Candida albicans
Departments of 1 Experimental Medicine and Biochemical Science and 2 Clinical and Experimental Medicine, University of Perugia, 06122 Perugia, Italy 3 Department of Immunology and Cell Biology, Mario Negri Institute, 20100 Milan, Italy 4 Department of Human and Clinical Genetics, Leiden University Medical Center, 2300 RA Leiden, The Netherlands 5 Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20007, USA
Correspondence to: L. Romani; E-mail: lromani{at}unipg.it
Transmitting editor: G. Trinchieri
Dendritic cells (DC) sense saprophytic yeast and pathogenic, filamentous forms of Candida albicans in a specific way, resulting in disparate patterns of DC and Th cell activation. Using human and murine DC, such disparate patterns could be traced to the exploitation of distinct recognition receptors. Although usage of mannose receptors led to protective type 1 responses in mice, entry through Fc
receptors was responsible for suppression of mannose receptor-dependent reactivity, onset of type 2 responses and associated pathology. As the usage of distinct receptors selectively occurred with yeast or hyphal forms of the fungus, these findings suggest that the responsibility for pathogenicity of C. albicans is shared by the organism and DC, with implications for fungal virulence, immunity and vaccine development.
Keywords: Candida albicans, dendritic cell, dimorphism, receptor, Th
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