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International Immunology, Vol. 15, No. 9, pp. 1099-1104, September 2003
© 2003 Japanese Society for Immunology

OcaB regulates transitional B cell selection

Mila Jankovic1 and Michel C. Nussenzweig1,2

1 Laboratory of Molecular Immunology and 2 Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021-6399, USA

Correspondence to: M. C. Nussenzweig, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021-6399, USA. E-mail: nussen{at}mail.rockefeller.edu
Transmitting editor: J. V. Ravetch

OcaB, also known as Bob-1 or Obf-1, is a transcriptional co-activator which regulates Ig{kappa} gene transcription, recombination and receptor editing; it is required for normal development of transitional B cells and for germinal center formation. Here we report that abnormal B cell development in OcaB–/– mice results in a skewed Ig{kappa} repertoire including anti-DNA antibodies, suggesting that OcaB is essential for antibody repertoire selection. To determine whether OcaB is required for BCR-mediated B cell selection, we introduced a pre-recombined {alpha} hen egg lysozyme (HEL) Ig transgene into OcaB–/– mice. We find that in OcaB–/– mice expressing transgenic {alpha}HEL Ig bone marrow B cell development is normal up to the immature B cell stage, but fails to progress to the transitional B cell stage. We conclude that OcaB is required for normal selection of the antibody repertoire in developing B cells.

Keywords: anti-self antibodies, B cell selection, Ig repertoire, OcaB, transitional B cells


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